Dysplasia is more common in the distal than proximal colon in ulcerative colitis surveillance

Robert Goldstone, Steven Itzkowitz, Noam Harpaz, Thomas A. Ullman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: In patients with long-standing ulcerative colitis (UC), current dysplasia surveillance guidelines recommend four-quadrant biopsies every 10 cm throughout the colon. However, this may be inefficient if neoplastic lesions are localized in particular segments of the colorectum. The aim was to determine whether a difference exists in the anatomic distribution of dysplasia discovered in UC patients undergoing colonoscopic surveillance. Methods: From an institutional database of over 700 patients with UC who underwent two or more surveillance colonoscopies between 1994-2006, we identified all patients with flat (endoscopically invisible) low-grade dysplasia (fLGD) or advanced neoplasia (colorectal cancer [CRC] or high-grade dysplasia [HGD]). Pathology reports were reviewed regarding the anatomic location of all dysplastic lesions. Fisher's exact test was used to compare the frequencies of neoplasia among the different colonic segments. Results: We identified 103 patients who progressed to any neoplasia (fLGD, HGD, or CRC). These patients underwent a total of 396 colonoscopies. The mean age at first surveillance colonoscopy was 48.6 years, with a mean UC disease duration of 18.2 years; 100% had extensive disease. Fifty-five patients developed advanced neoplasia. The rectosigmoid was found to have a significantly greater number of biopsies positive for advanced neoplasia and for any neoplasia compared to all other colonic segments (P < 0.0007); 71.2% of all advanced neoplasia was in the rectosigmoid. Conclusions: The majority of dysplastic lesions identified in a surveillance program was detected in the rectosigmoid. Endoscopists should consider taking a greater percentage of biopsies in these segments as opposed to more proximal areas.

Original languageEnglish (US)
Pages (from-to)832-837
Number of pages6
JournalInflammatory Bowel Diseases
Volume18
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

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Ulcerative Colitis
Colon
Colonoscopy
Neoplasms
Biopsy
Colorectal Neoplasms
Databases
Guidelines
Pathology

Keywords

  • Biopsy location
  • Dysplasia
  • Surveillance colonoscopy
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Dysplasia is more common in the distal than proximal colon in ulcerative colitis surveillance. / Goldstone, Robert; Itzkowitz, Steven; Harpaz, Noam; Ullman, Thomas A.

In: Inflammatory Bowel Diseases, Vol. 18, No. 5, 01.05.2012, p. 832-837.

Research output: Contribution to journalArticle

Goldstone, Robert ; Itzkowitz, Steven ; Harpaz, Noam ; Ullman, Thomas A. / Dysplasia is more common in the distal than proximal colon in ulcerative colitis surveillance. In: Inflammatory Bowel Diseases. 2012 ; Vol. 18, No. 5. pp. 832-837.
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