Dyslipoproteinemia in pediatric systemic lupus erythematosus

Norman T. Ilowite, Paul Samuel, Ellen Ginzler, Marc S. Jacobson

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Patients with systemic lupus erythematosus are at increased risk for premature atherosclerosis. We examined one possible etiologic factor, dyslipoproteinemia, both before and after corticosteroid therapy. We identified 2 distinct patterns of dyslipoproteinemia. One is attributable to active disease; the other is attributable, in part, to corticosteroid therapy. The dyslipoproteinemia of active disease consists of depressed high density lipoprotein cholesterol and apoprotein A‐I with elevated very low density lipoprotein cholesterol and triglyceride, while the dyslipoproteinemia after corticosteroid therapy consists of increased total cholesterol, very low density lipoprotein cholesterol, and triglyceride. The possible pathophysiologic mechanisms responsible for these patterns, as well as the possible roles in premature atherosclerosis seen in systemic lupus erythematosus patients, are discussed.

Original languageEnglish (US)
Pages (from-to)859-863
Number of pages5
JournalArthritis & Rheumatism
Volume31
Issue number7
DOIs
StatePublished - Jul 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Dyslipoproteinemia in pediatric systemic lupus erythematosus'. Together they form a unique fingerprint.

  • Cite this

    Ilowite, N. T., Samuel, P., Ginzler, E., & Jacobson, M. S. (1988). Dyslipoproteinemia in pediatric systemic lupus erythematosus. Arthritis & Rheumatism, 31(7), 859-863. https://doi.org/10.1002/art.1780310706