Dyslipoproteinemia in murine systemic lupus erythematosus

Marc S. Jacobson, Howard Trachtman, Joseph Feldman, Paul Samuel, Norman T. Ilowite

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Abstract

Dyslipoproteinemia, a feature of systemic lupus erythematosus may contribute to premature atherosclerosis. In order to develop an experimental model for this dyslipoproteinemia we measured plasma concentrations of lipoproteins in juvenile NZB/W (lupus) and NZB/B (control) mice. Additionally to evaluate the effects of a diet rich in n - 3 fatty acids we measured lipoprotein concentrations in mice on normal or menhaden oil-enriched diets. The lupus mice had elevated triglycerides compared to the controls, similar to that seen in human SLE patients (161 ± 31 vs. 113 ± 13 mg/dl, P < 0.003). In contrast, the menhaden oil diet fed NZB/W mice had triglycerides similar to the NZB/B control fed group. In the NZB/W murine SLE model, dyslipoproteinemia is an early sign of disease as has been shown in man, therefore this model will be useful in elucidating the mechanism of dyslipoproteinemia in SLE.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalAtherosclerosis
Volume79
Issue number2-3
DOIs
Publication statusPublished - Oct 1989

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Keywords

  • Dyslipoproteinemia
  • Lupus erythematosus
  • Menhaden oil
  • NZB/W mouse

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Jacobson, M. S., Trachtman, H., Feldman, J., Samuel, P., & Ilowite, N. T. (1989). Dyslipoproteinemia in murine systemic lupus erythematosus. Atherosclerosis, 79(2-3), 205-211. https://doi.org/10.1016/0021-9150(89)90125-1