Dyskinesis in chagasic myocardium: centerline analysis of wall motion using cardiac-gated magnetic resonance images of mice

Jorge L. Durand, Baiyu Tang, David E. Gutstein, Stefka Petkova, Mauro M. Teixeira, Herbert B. Tanowitz, Linda A. Jelicks

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We report on the use of centerline analysis of cardiac-gated magnetic resonance images to measure wall motion abnormalities in mice infected with Trypanosoma cruzi. To our knowledge, this is the first report of segmental wall motion abnormalities in an animal model of Chagas' disease. Chagas' disease patients with severe cardiac involvement exhibit mild hypokinesis in an extensive region of the left ventricle and dyskinesis in the apical region. We observed dyskinetic segments in a similar region of the hearts of infected wild-type mice. Dyskinesis was not observed in infected mice lacking macrophage inflammatory protein-1α, a chemokine that may play an important role in the cardiac remodeling that is normally observed in mouse models of Chagas' disease and in human patients. This study aimed to demonstrate the utility of cardiac-gated magnetic resonance imaging and centerline analysis as a straightforward method for monitoring regional left ventricular wall motion in transgenic and/or diseased mice.

Original languageEnglish (US)
Pages (from-to)1051-1057
Number of pages7
JournalMagnetic Resonance Imaging
Volume24
Issue number8
DOIs
StatePublished - Oct 1 2006

Keywords

  • Cardiac gated
  • Centerline
  • Left ventricle
  • Magnetic resonance imaging
  • Mice
  • Wall motion

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Durand, J. L., Tang, B., Gutstein, D. E., Petkova, S., Teixeira, M. M., Tanowitz, H. B., & Jelicks, L. A. (2006). Dyskinesis in chagasic myocardium: centerline analysis of wall motion using cardiac-gated magnetic resonance images of mice. Magnetic Resonance Imaging, 24(8), 1051-1057. https://doi.org/10.1016/j.mri.2006.04.001