Abstract
Objective The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. Methods A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. Results A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]). Conclusion Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 312-319 |
| Number of pages | 8 |
| Journal | Journal of the American Medical Directors Association |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2017 |
Keywords
- Muscle strength
- aging
- metabolic syndrome
- obesity
ASJC Scopus subject areas
- Nursing(all)
- Health Policy
- Geriatrics and Gerontology
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Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older : The LIFE Study. / Aubertin-Leheudre, Mylène; Anton, Stephen; Beavers, Daniel P.; Manini, Todd M.; Fielding, Roger; Newman, Ann; Church, Tim; Kritchevsky, Stephen B.; Conroy, David; McDermott, Mary M.; Botoseneanu, Anda; Hauser, Michelle E.; Pahor, Marco; Gill, Thomas; Fragoso, Carlos; Fielding, Roger; Hauser, Michelle E.; Pahor, Marco; Guralnik, Jack M.; Leeuwenburgh, Christiaan; Caudle, Connie; Crump, Lauren; Holmes, Latonia; Lee, Jocelyn; Lu, Ching ju; Miller, Michael E.; Espeland, Mark A.; Ambrosius, Walter T.; Applegate, William; Beavers, Daniel P.; Byington, Robert P.; Cook, Delilah; Furberg, Curt D.; Harvin, Lea N.; Henkin, Leora; Hepler, Med John; Hsu, Fang Chi; Lovato, Laura; Roberson, Wesley; Rushing, Julia; Rushing, Scott; Stowe, Cynthia L.; Walkup, Michael P.; Hire, Don; Rejeski, W. Jack; Katula, Jeffrey A.; Brubaker, Peter H.; Mihalko, Shannon L.; Jennings, Janine M.; Hadley, Evan C.; Romashkan, Sergei; Patel, Kushang V.; Bonds, Denise; McDermott, Mary M.; Spring, Bonnie; Hauser, Joshua; Kerwin, Diana; Domanchuk, Kathryn; Graff, Rex; Rego, Alvito; Church, Timothy S.; Blair, Steven N.; Myers, Valerie H.; Monce, Ron; Britt, Nathan E.; Harris, Melissa Nauta; McGucken, Ami Parks; Rodarte, Ruben; Millet, Heidi K.; Tudor-Locke, Catrine; Butitta, Ben P.; Donatto, Sheletta G.; Cocreham, Shannon H.; King, Abby C.; Castro, Cynthia M.; Haskell, William L.; Stafford, Randall S.; Pruitt, Leslie A.; Berra, Kathy; Yank, Veronica; Fielding, Roger A.; Nelson, Miriam E.; Folta, Sara C.; Phillips, Edward M.; Liu, Christine K.; McDavitt, Erica C.; Reid, Kieran F.; Kirn, Dylan R.; Pasha, Evan P.; Kim, Won S.; Beard, Vince E.; Tsiroyannis, Eleni X.; Hau, Cynthia; Manini, Todd M.; Pahor, Marco; Anton, Stephen D.; Nayfield, Susan; Buford, Thomas W.; Marsiske, Michael; Sandesara, Bhanuprasad D.; Knaggs, Jeffrey D.; Lorow, Megan S.; Marena, William C.; Korytov, Irina; Morris, Holly L.; Fitch, Margo; Singletary, Floris F.; Causer, Jackie; Radcliff, Katie A.; Newman, Anne B.; Studenski, Stephanie A.; Goodpaster, Bret H.; Glynn, Nancy W.; Lopez, Oscar; Nadkarni, Neelesh K.; Williams, Kathy; Newman, Mark A.; Grove, George; Bonk, Janet T.; Rush, Jennifer; Kost, Piera; Ives, Diane G.; Kritchevsky, Stephen B.; Marsh, Anthony P.; Brinkley, Tina E.; Demons, Jamehl S.; Sink, Kaycee M.; Kennedy, Kimberly; Shertzer-Skinner, Rachel; Wrights, Abbie; Fries, Rose; Barr, Deborah; Gill, Thomas M.; Axtell, Robert S.; Kashaf, Susan S.; de Rekeneire, Nathalie; McGloin, Joanne M.; Wu, Karen C.; Shepard, Denise M.; Fennelly, Barbara; Iannone, Lynne P.; Mautner, Raeleen; Barnett, Theresa Sweeney; Halpin, Sean N.; Brennan, Matthew J.; Bugaj, Julie A.; Zenoni, Maria A.; Mignosa, Bridget M.; Williamson, Jeff; Sink, Kaycee M.; Hendrie, Hugh C.; Rapp, Stephen R.; Verghese, Joe; Woolard, Nancy; Espeland, Mark; Jennings, Janine; Wilson, Valerie K.; Pepine, Carl J.; Ariet, Mario; Handberg, Eileen; Deluca, Daniel; Hill, James; Szady, Anita; Chupp, Geoffrey L.; Flynn, Gail M.; Gill, Thomas M.; Hankinson, John L.; Vaz Fragoso, Carlos A.; Groessl, Erik J.; Kaplan, Robert M.
In: Journal of the American Medical Directors Association, Vol. 18, No. 4, 01.04.2017, p. 312-319.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older
T2 - The LIFE Study
AU - Aubertin-Leheudre, Mylène
AU - Anton, Stephen
AU - Beavers, Daniel P.
AU - Manini, Todd M.
AU - Fielding, Roger
AU - Newman, Ann
AU - Church, Tim
AU - Kritchevsky, Stephen B.
AU - Conroy, David
AU - McDermott, Mary M.
AU - Botoseneanu, Anda
AU - Hauser, Michelle E.
AU - Pahor, Marco
AU - Gill, Thomas
AU - Fragoso, Carlos
AU - Fielding, Roger
AU - Hauser, Michelle E.
AU - Pahor, Marco
AU - Guralnik, Jack M.
AU - Leeuwenburgh, Christiaan
AU - Caudle, Connie
AU - Crump, Lauren
AU - Holmes, Latonia
AU - Lee, Jocelyn
AU - Lu, Ching ju
AU - Miller, Michael E.
AU - Espeland, Mark A.
AU - Ambrosius, Walter T.
AU - Applegate, William
AU - Beavers, Daniel P.
AU - Byington, Robert P.
AU - Cook, Delilah
AU - Furberg, Curt D.
AU - Harvin, Lea N.
AU - Henkin, Leora
AU - Hepler, Med John
AU - Hsu, Fang Chi
AU - Lovato, Laura
AU - Roberson, Wesley
AU - Rushing, Julia
AU - Rushing, Scott
AU - Stowe, Cynthia L.
AU - Walkup, Michael P.
AU - Hire, Don
AU - Rejeski, W. Jack
AU - Katula, Jeffrey A.
AU - Brubaker, Peter H.
AU - Mihalko, Shannon L.
AU - Jennings, Janine M.
AU - Hadley, Evan C.
AU - Romashkan, Sergei
AU - Patel, Kushang V.
AU - Bonds, Denise
AU - McDermott, Mary M.
AU - Spring, Bonnie
AU - Hauser, Joshua
AU - Kerwin, Diana
AU - Domanchuk, Kathryn
AU - Graff, Rex
AU - Rego, Alvito
AU - Church, Timothy S.
AU - Blair, Steven N.
AU - Myers, Valerie H.
AU - Monce, Ron
AU - Britt, Nathan E.
AU - Harris, Melissa Nauta
AU - McGucken, Ami Parks
AU - Rodarte, Ruben
AU - Millet, Heidi K.
AU - Tudor-Locke, Catrine
AU - Butitta, Ben P.
AU - Donatto, Sheletta G.
AU - Cocreham, Shannon H.
AU - King, Abby C.
AU - Castro, Cynthia M.
AU - Haskell, William L.
AU - Stafford, Randall S.
AU - Pruitt, Leslie A.
AU - Berra, Kathy
AU - Yank, Veronica
AU - Fielding, Roger A.
AU - Nelson, Miriam E.
AU - Folta, Sara C.
AU - Phillips, Edward M.
AU - Liu, Christine K.
AU - McDavitt, Erica C.
AU - Reid, Kieran F.
AU - Kirn, Dylan R.
AU - Pasha, Evan P.
AU - Kim, Won S.
AU - Beard, Vince E.
AU - Tsiroyannis, Eleni X.
AU - Hau, Cynthia
AU - Manini, Todd M.
AU - Pahor, Marco
AU - Anton, Stephen D.
AU - Nayfield, Susan
AU - Buford, Thomas W.
AU - Marsiske, Michael
AU - Sandesara, Bhanuprasad D.
AU - Knaggs, Jeffrey D.
AU - Lorow, Megan S.
AU - Marena, William C.
AU - Korytov, Irina
AU - Morris, Holly L.
AU - Fitch, Margo
AU - Singletary, Floris F.
AU - Causer, Jackie
AU - Radcliff, Katie A.
AU - Newman, Anne B.
AU - Studenski, Stephanie A.
AU - Goodpaster, Bret H.
AU - Glynn, Nancy W.
AU - Lopez, Oscar
AU - Nadkarni, Neelesh K.
AU - Williams, Kathy
AU - Newman, Mark A.
AU - Grove, George
AU - Bonk, Janet T.
AU - Rush, Jennifer
AU - Kost, Piera
AU - Ives, Diane G.
AU - Kritchevsky, Stephen B.
AU - Marsh, Anthony P.
AU - Brinkley, Tina E.
AU - Demons, Jamehl S.
AU - Sink, Kaycee M.
AU - Kennedy, Kimberly
AU - Shertzer-Skinner, Rachel
AU - Wrights, Abbie
AU - Fries, Rose
AU - Barr, Deborah
AU - Gill, Thomas M.
AU - Axtell, Robert S.
AU - Kashaf, Susan S.
AU - de Rekeneire, Nathalie
AU - McGloin, Joanne M.
AU - Wu, Karen C.
AU - Shepard, Denise M.
AU - Fennelly, Barbara
AU - Iannone, Lynne P.
AU - Mautner, Raeleen
AU - Barnett, Theresa Sweeney
AU - Halpin, Sean N.
AU - Brennan, Matthew J.
AU - Bugaj, Julie A.
AU - Zenoni, Maria A.
AU - Mignosa, Bridget M.
AU - Williamson, Jeff
AU - Sink, Kaycee M.
AU - Hendrie, Hugh C.
AU - Rapp, Stephen R.
AU - Verghese, Joe
AU - Woolard, Nancy
AU - Espeland, Mark
AU - Jennings, Janine
AU - Wilson, Valerie K.
AU - Pepine, Carl J.
AU - Ariet, Mario
AU - Handberg, Eileen
AU - Deluca, Daniel
AU - Hill, James
AU - Szady, Anita
AU - Chupp, Geoffrey L.
AU - Flynn, Gail M.
AU - Gill, Thomas M.
AU - Hankinson, John L.
AU - Vaz Fragoso, Carlos A.
AU - Groessl, Erik J.
AU - Kaplan, Robert M.
N1 - Publisher Copyright: © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Objective The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. Methods A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. Results A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]). Conclusion Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.
AB - Objective The purpose of this study was to examine the relationship between dynapenia and metabolic risk factors in obese and nonobese older adults. Methods A total of 1453 men and women (age ≥70 years) from the Lifestyle Interventions and Independence for Elders (LIFE) Study were categorized as (1) nondynapenic/nonobese (NDYN-NO), (2) dynapenic/nonobese (DYN-NO), (3) nondynapenic/obese (NDYN-O), or (4) dynapenic/obese (DYN-O), based on muscle strength (Foundation for the National Institute of Health criteria) and body mass index. Dependent variables were blood lipids, fasting glucose, blood pressure, presence of at least 3 metabolic syndrome (MetS) criteria, and other chronic conditions. Results A significantly higher likelihood of having abdominal obesity criteria in NDYN-NO compared with DYN-NO groups (55.6 vs 45.1%, P ≤ .01) was observed. Waist circumference also was significantly higher in obese groups (DYN-O = 114.0 ± 12.9 and NDYN-O = 111.2 ± 13.1) than in nonobese (NDYN-NO = 93.1 ± 10.7 and DYN-NO = 92.2 ± 11.2, P ≤ .01); and higher in NDYN-O compared with DYN-O (P = .008). Additionally, NDYN-O demonstrated higher diastolic blood pressure compared with DYN-O (70.9 ± 10.1 vs 67.7 ± 9.7, P ≤ .001). No significant differences were found across dynapenia and obesity status for all other metabolic components (P > .05). The odds of having MetS or its individual components were similar in obese and nonobese, combined or not with dynapenia (nonsignificant odds ratio [95% confidence interval]). Conclusion Nonobese dynapenic older adults had fewer metabolic disease risk factors than nonobese and nondynapenic older adults. Moreover, among obese older adults, dynapenia was associated with lower risk of meeting MetS criteria for waist circumference and diastolic blood pressure. Additionally, the presence of dynapenia did not increase cardiometabolic disease risk in either obese or nonobese older adults.
KW - Muscle strength
KW - aging
KW - metabolic syndrome
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85007449384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007449384&partnerID=8YFLogxK
U2 - 10.1016/j.jamda.2016.10.001
DO - 10.1016/j.jamda.2016.10.001
M3 - Article
C2 - 27914851
AN - SCOPUS:85007449384
VL - 18
SP - 312
EP - 319
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
SN - 1525-8610
IS - 4
ER -