Dynamics of transcription and mRNA export

Xavier Darzacq; Robert H. Singer; Yaron Shav-Tal

doi:10.1016/j.ceb.2005.04.004

Dynamics of transcription and mRNA export

Xavier Darzacq, Robert H. Singer, Yaron Shav-Tal

Cell Biology

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.

Original language	English (US)
Pages (from-to)	332-339
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/j.ceb.2005.04.004
State	Published - Jun 2005

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2005.04.004

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title = "Dynamics of transcription and mRNA export",

abstract = "Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.",

author = "Xavier Darzacq and Singer, {Robert H.} and Yaron Shav-Tal",

note = "Funding Information: We thank Olivier Bensaude and Claire Dugast-Darzacq for critical reading of the manuscript. This work was supported by grants from the NIH EB 2060, DOE ER63056 and P20 EB4930 to RHS.",

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AU - Singer, Robert H.

AU - Shav-Tal, Yaron

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PY - 2005/6

Y1 - 2005/6

N2 - Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.

AB - Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.

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Dynamics of transcription and mRNA export

Abstract

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