Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998.

Violeta Chitu, C. C. Diaconu, D. Veliceasa, S. Ruţǎ, C. Grancea, G. Târdei, C. E. Cernescu

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Variability is a hallmark of HIV viruses both at the genetic and the phenotypic level. Viral sequencing and phylogenetic analysis of many isolates revealed specific distribution of HIV-1 subtypes according to the geographic location and route of transmission. In Romania, the currently available data coming from the study of pediatric HIV infection suggest the predominance of subtype F. However, there are few data concerning the distribution of HIV-1 subtypes among adults. We investigated the changes in the distribution of different HIV-1 subtypes among HIV-1 infected adult patients from Bucharest over a 6 years period (1992-1998) by means of V3 binding assays. The analysis of the relative incidence of different HIV-1 serotypes revealed the steady predominance of serotype F (50-75%) among the adults from Bucharest and a small but constant increase of the number of samples with serotype B- from 5% in 1994 to 14% in 1998. In contrast, the serotype E is either absent or weakly represented (4%) during the period of the study. All over the years there was a relatively high proportion (6-30%) of non-reactive samples. This could be an indication for the possible emergence of new or recombinant HIV-1 subtypes.

Original languageEnglish (US)
Title of host publicationRomanian journal of virology
Pages43-51
Number of pages9
Volume50
Edition1-4
StatePublished - Jan 1999
Externally publishedYes

Fingerprint

HIV-1
Geographic Locations
Romania
HIV Infections
HIV
Pediatrics
Viruses
Serogroup
Incidence

ASJC Scopus subject areas

  • Virology

Cite this

Chitu, V., Diaconu, C. C., Veliceasa, D., Ruţǎ, S., Grancea, C., Târdei, G., & Cernescu, C. E. (1999). Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998. In Romanian journal of virology (1-4 ed., Vol. 50, pp. 43-51)

Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998. / Chitu, Violeta; Diaconu, C. C.; Veliceasa, D.; Ruţǎ, S.; Grancea, C.; Târdei, G.; Cernescu, C. E.

Romanian journal of virology. Vol. 50 1-4. ed. 1999. p. 43-51.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chitu, V, Diaconu, CC, Veliceasa, D, Ruţǎ, S, Grancea, C, Târdei, G & Cernescu, CE 1999, Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998. in Romanian journal of virology. 1-4 edn, vol. 50, pp. 43-51.
Chitu V, Diaconu CC, Veliceasa D, Ruţǎ S, Grancea C, Târdei G et al. Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998. In Romanian journal of virology. 1-4 ed. Vol. 50. 1999. p. 43-51
Chitu, Violeta ; Diaconu, C. C. ; Veliceasa, D. ; Ruţǎ, S. ; Grancea, C. ; Târdei, G. ; Cernescu, C. E. / Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998. Romanian journal of virology. Vol. 50 1-4. ed. 1999. pp. 43-51
@inbook{e76e9e128d934d7690b1d7e6669b1747,
title = "Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998.",
abstract = "Variability is a hallmark of HIV viruses both at the genetic and the phenotypic level. Viral sequencing and phylogenetic analysis of many isolates revealed specific distribution of HIV-1 subtypes according to the geographic location and route of transmission. In Romania, the currently available data coming from the study of pediatric HIV infection suggest the predominance of subtype F. However, there are few data concerning the distribution of HIV-1 subtypes among adults. We investigated the changes in the distribution of different HIV-1 subtypes among HIV-1 infected adult patients from Bucharest over a 6 years period (1992-1998) by means of V3 binding assays. The analysis of the relative incidence of different HIV-1 serotypes revealed the steady predominance of serotype F (50-75{\%}) among the adults from Bucharest and a small but constant increase of the number of samples with serotype B- from 5{\%} in 1994 to 14{\%} in 1998. In contrast, the serotype E is either absent or weakly represented (4{\%}) during the period of the study. All over the years there was a relatively high proportion (6-30{\%}) of non-reactive samples. This could be an indication for the possible emergence of new or recombinant HIV-1 subtypes.",
author = "Violeta Chitu and Diaconu, {C. C.} and D. Veliceasa and S. Ruţǎ and C. Grancea and G. T{\^a}rdei and Cernescu, {C. E.}",
year = "1999",
month = "1",
language = "English (US)",
volume = "50",
pages = "43--51",
booktitle = "Romanian journal of virology",
edition = "1-4",

}

TY - CHAP

T1 - Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998.

AU - Chitu, Violeta

AU - Diaconu, C. C.

AU - Veliceasa, D.

AU - Ruţǎ, S.

AU - Grancea, C.

AU - Târdei, G.

AU - Cernescu, C. E.

PY - 1999/1

Y1 - 1999/1

N2 - Variability is a hallmark of HIV viruses both at the genetic and the phenotypic level. Viral sequencing and phylogenetic analysis of many isolates revealed specific distribution of HIV-1 subtypes according to the geographic location and route of transmission. In Romania, the currently available data coming from the study of pediatric HIV infection suggest the predominance of subtype F. However, there are few data concerning the distribution of HIV-1 subtypes among adults. We investigated the changes in the distribution of different HIV-1 subtypes among HIV-1 infected adult patients from Bucharest over a 6 years period (1992-1998) by means of V3 binding assays. The analysis of the relative incidence of different HIV-1 serotypes revealed the steady predominance of serotype F (50-75%) among the adults from Bucharest and a small but constant increase of the number of samples with serotype B- from 5% in 1994 to 14% in 1998. In contrast, the serotype E is either absent or weakly represented (4%) during the period of the study. All over the years there was a relatively high proportion (6-30%) of non-reactive samples. This could be an indication for the possible emergence of new or recombinant HIV-1 subtypes.

AB - Variability is a hallmark of HIV viruses both at the genetic and the phenotypic level. Viral sequencing and phylogenetic analysis of many isolates revealed specific distribution of HIV-1 subtypes according to the geographic location and route of transmission. In Romania, the currently available data coming from the study of pediatric HIV infection suggest the predominance of subtype F. However, there are few data concerning the distribution of HIV-1 subtypes among adults. We investigated the changes in the distribution of different HIV-1 subtypes among HIV-1 infected adult patients from Bucharest over a 6 years period (1992-1998) by means of V3 binding assays. The analysis of the relative incidence of different HIV-1 serotypes revealed the steady predominance of serotype F (50-75%) among the adults from Bucharest and a small but constant increase of the number of samples with serotype B- from 5% in 1994 to 14% in 1998. In contrast, the serotype E is either absent or weakly represented (4%) during the period of the study. All over the years there was a relatively high proportion (6-30%) of non-reactive samples. This could be an indication for the possible emergence of new or recombinant HIV-1 subtypes.

UR - http://www.scopus.com/inward/record.url?scp=0032601064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032601064&partnerID=8YFLogxK

M3 - Chapter

C2 - 11601379

AN - SCOPUS:0032601064

VL - 50

SP - 43

EP - 51

BT - Romanian journal of virology

ER -