Dynamics of electrical transmission at club endings on the Mauthner cells

Alberto E. Pereda, John E. Rash, James I. Nagy, Michael V.L. Bennett

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Identifiable mixed electrical and chemical synapses on Mauthner cells, the club endings, have historically provided a window for the study of electrical transmission in vertebrates because of their accessibility for both physiological and ultrastructural characterization. Recent data show that electrical transmission at these terminals is mediated by connexin35 (Cx35), the fish ortholog of the mammalian neuronal gap junction protein, connexin36 (Cx36). While electrical synapses are still perceived by many as passive intercellular channels that lack modifiability, a wealth of experimental evidence shows that electrical synapses at club endings are very plastic and subject to dynamic regulatory control by several mechanisms. The widespread distribution of connexin35 and connexin36 and the ubiquity of some of the proposed regulatory elements suggest that other electrical synapses may be similarly regulated.

Original languageEnglish (US)
Pages (from-to)227-244
Number of pages18
JournalBrain Research Reviews
Volume47
Issue number1-3
DOIs
StatePublished - Dec 1 2004

Keywords

  • Auditory
  • Connexin35
  • Connexin36
  • Dopamine
  • Electrical Coupling
  • Electrical synapse
  • Excitable membranes and synaptic transmission
  • Gap junction
  • Long-term potentiation
  • NMDA
  • Other ion channels
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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