Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Yuelin Song, Patrick R. van den Berg, Styliani Markoulaki, Frank Soldner, Alessandra Dall'Agnese, Jonathan E. Henninger, Jesse Drotar, Nicholas Rosenau, Malkiel A. Cohen, Richard A. Young, Stefan Semrau, Yonatan Stelzer, Rudolf Jaenisch

Research output: Contribution to journalArticle

Abstract

Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

Original languageEnglish (US)
Pages (from-to)905-920.e6
JournalMolecular Cell
Volume75
Issue number5
DOIs
StatePublished - Sep 5 2019
Externally publishedYes

Fingerprint

DNA Methylation
Mouse Embryonic Stem Cells

Keywords

  • dynamic DNA methylation
  • embryonic stem cells
  • super-enhancers
  • transcriptional heterogeneity

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Song, Y., van den Berg, P. R., Markoulaki, S., Soldner, F., Dall'Agnese, A., Henninger, J. E., ... Jaenisch, R. (2019). Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Molecular Cell, 75(5), 905-920.e6. https://doi.org/10.1016/j.molcel.2019.06.045

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. / Song, Yuelin; van den Berg, Patrick R.; Markoulaki, Styliani; Soldner, Frank; Dall'Agnese, Alessandra; Henninger, Jonathan E.; Drotar, Jesse; Rosenau, Nicholas; Cohen, Malkiel A.; Young, Richard A.; Semrau, Stefan; Stelzer, Yonatan; Jaenisch, Rudolf.

In: Molecular Cell, Vol. 75, No. 5, 05.09.2019, p. 905-920.e6.

Research output: Contribution to journalArticle

Song, Y, van den Berg, PR, Markoulaki, S, Soldner, F, Dall'Agnese, A, Henninger, JE, Drotar, J, Rosenau, N, Cohen, MA, Young, RA, Semrau, S, Stelzer, Y & Jaenisch, R 2019, 'Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs', Molecular Cell, vol. 75, no. 5, pp. 905-920.e6. https://doi.org/10.1016/j.molcel.2019.06.045
Song, Yuelin ; van den Berg, Patrick R. ; Markoulaki, Styliani ; Soldner, Frank ; Dall'Agnese, Alessandra ; Henninger, Jonathan E. ; Drotar, Jesse ; Rosenau, Nicholas ; Cohen, Malkiel A. ; Young, Richard A. ; Semrau, Stefan ; Stelzer, Yonatan ; Jaenisch, Rudolf. / Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. In: Molecular Cell. 2019 ; Vol. 75, No. 5. pp. 905-920.e6.
@article{319d86d9c38448c69a988ed710f84f7a,
title = "Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs",
abstract = "Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.",
keywords = "dynamic DNA methylation, embryonic stem cells, super-enhancers, transcriptional heterogeneity",
author = "Yuelin Song and {van den Berg}, {Patrick R.} and Styliani Markoulaki and Frank Soldner and Alessandra Dall'Agnese and Henninger, {Jonathan E.} and Jesse Drotar and Nicholas Rosenau and Cohen, {Malkiel A.} and Young, {Richard A.} and Stefan Semrau and Yonatan Stelzer and Rudolf Jaenisch",
year = "2019",
month = "9",
day = "5",
doi = "10.1016/j.molcel.2019.06.045",
language = "English (US)",
volume = "75",
pages = "905--920.e6",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

AU - Song, Yuelin

AU - van den Berg, Patrick R.

AU - Markoulaki, Styliani

AU - Soldner, Frank

AU - Dall'Agnese, Alessandra

AU - Henninger, Jonathan E.

AU - Drotar, Jesse

AU - Rosenau, Nicholas

AU - Cohen, Malkiel A.

AU - Young, Richard A.

AU - Semrau, Stefan

AU - Stelzer, Yonatan

AU - Jaenisch, Rudolf

PY - 2019/9/5

Y1 - 2019/9/5

N2 - Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

AB - Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

KW - dynamic DNA methylation

KW - embryonic stem cells

KW - super-enhancers

KW - transcriptional heterogeneity

UR - http://www.scopus.com/inward/record.url?scp=85071542699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071542699&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2019.06.045

DO - 10.1016/j.molcel.2019.06.045

M3 - Article

C2 - 31422875

AN - SCOPUS:85071542699

VL - 75

SP - 905-920.e6

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 5

ER -