Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Yuelin Song; Patrick R. van den Berg; Styliani Markoulaki; Frank Soldner; Alessandra Dall'Agnese; Jonathan E. Henninger; Jesse Drotar; Nicholas Rosenau; Malkiel A. Cohen; Richard A. Young; Stefan Semrau; Yonatan Stelzer; Rudolf Jaenisch

doi:10.1016/j.molcel.2019.06.045

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Yuelin Song, Patrick R. van den Berg, Styliani Markoulaki, Frank Soldner, Alessandra Dall'Agnese, Jonathan E. Henninger, Jesse Drotar, Nicholas Rosenau, Malkiel A. Cohen, Richard A. Young, Stefan Semrau, Yonatan Stelzer, Rudolf Jaenisch

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

Original language	English (US)
Pages (from-to)	905-920.e6
Journal	Molecular Cell
Volume	75
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2019.06.045
State	Published - Sep 5 2019
Externally published	Yes

Keywords

dynamic DNA methylation
embryonic stem cells
super-enhancers
transcriptional heterogeneity

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1016/j.molcel.2019.06.045

Cite this

Song, Y., van den Berg, P. R., Markoulaki, S., Soldner, F., Dall'Agnese, A., Henninger, J. E., Drotar, J., Rosenau, N., Cohen, M. A., Young, R. A., Semrau, S., Stelzer, Y., & Jaenisch, R. (2019). Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Molecular Cell, 75(5), 905-920.e6. https://doi.org/10.1016/j.molcel.2019.06.045

@article{319d86d9c38448c69a988ed710f84f7a,

title = "Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs",

abstract = "Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.",

keywords = "dynamic DNA methylation, embryonic stem cells, super-enhancers, transcriptional heterogeneity",

author = "Yuelin Song and {van den Berg}, {Patrick R.} and Styliani Markoulaki and Frank Soldner and Alessandra Dall'Agnese and Henninger, {Jonathan E.} and Jesse Drotar and Nicholas Rosenau and Cohen, {Malkiel A.} and Young, {Richard A.} and Stefan Semrau and Yonatan Stelzer and Rudolf Jaenisch",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "5",

doi = "10.1016/j.molcel.2019.06.045",

language = "English (US)",

volume = "75",

pages = "905--920.e6",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

AU - Song, Yuelin

AU - van den Berg, Patrick R.

AU - Markoulaki, Styliani

AU - Soldner, Frank

AU - Dall'Agnese, Alessandra

AU - Henninger, Jonathan E.

AU - Drotar, Jesse

AU - Rosenau, Nicholas

AU - Cohen, Malkiel A.

AU - Young, Richard A.

AU - Semrau, Stefan

AU - Stelzer, Yonatan

AU - Jaenisch, Rudolf

PY - 2019/9/5

Y1 - 2019/9/5

N2 - Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

AB - Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

KW - dynamic DNA methylation

KW - embryonic stem cells

KW - super-enhancers

KW - transcriptional heterogeneity

UR - http://www.scopus.com/inward/record.url?scp=85071542699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071542699&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2019.06.045

DO - 10.1016/j.molcel.2019.06.045

M3 - Article

C2 - 31422875

AN - SCOPUS:85071542699

SN - 1097-2765

VL - 75

SP - 905-920.e6

JO - Molecular Cell

JF - Molecular Cell

IS - 5

ER -

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this