Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs

Yuelin Song, Patrick R. van den Berg, Styliani Markoulaki, Frank Soldner, Alessandra Dall'Agnese, Jonathan E. Henninger, Jesse Drotar, Nicholas Rosenau, Malkiel A. Cohen, Richard A. Young, Stefan Semrau, Yonatan Stelzer, Rudolf Jaenisch

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Song et al. used an allelic reporter approach to show super-enhancers allelic DNA methylation dynamics underlies locus-specific heterogeneity, which functionally impacts transcription and cellular states of mouse embryonic stem cells.

Original languageEnglish (US)
Pages (from-to)905-920.e6
JournalMolecular Cell
Volume75
Issue number5
DOIs
StatePublished - Sep 5 2019

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Keywords

  • dynamic DNA methylation
  • embryonic stem cells
  • super-enhancers
  • transcriptional heterogeneity

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Song, Y., van den Berg, P. R., Markoulaki, S., Soldner, F., Dall'Agnese, A., Henninger, J. E., Drotar, J., Rosenau, N., Cohen, M. A., Young, R. A., Semrau, S., Stelzer, Y., & Jaenisch, R. (2019). Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Molecular Cell, 75(5), 905-920.e6. https://doi.org/10.1016/j.molcel.2019.06.045