Duration of chronic kidney disease reduces attention and executive function in pediatric patients

Susan R. Mendley, Matthew B. Matheson, Shlomo Shinnar, Marc B. Lande, Arlene C. Gerson, Robert W. Butler, Bradley A. Warady, Susan L. Furth, Stephen R. Hooper

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) in childhood is associated with neurocognitive deficits. Affected children show worse performance on tests of intelligence than their unaffected siblings and skew toward the lower end of the normal range. Here we further assessed this association in 340 pediatric patients (ages 6-21) with mild-moderate CKD in the Chronic Kidney Disease in Childhood cohort from 48 pediatric centers in North America. Participants underwent a battery of age-appropriate tests including Conners' Continuous Performance Test-II (CPT-II), Delis-Kaplan Executive Function System Tower task, and the Digit Span Backward task from the age-appropriate Wechsler Intelligence Scale. Test performance was compared across the range of estimated glomerular filtration rate and duration of CKD with relevant covariates including maternal education, household income, IQ, blood pressure, and preterm birth. Among the 340 patients, 35% had poor performance (below the mean by 1.5 or more standard deviations) on at least one test of executive function. By univariate nonparametric comparison and multiple logistic regression, longer duration of CKD was associated with increased odds ratio for poor performance on the CPT-II Errors of Commission, a test of attention regulation and inhibitory control. Thus, in a population with mild-to-moderate CKD, the duration of disease rather than estimated glomerular filtration rate was associated with impaired attention regulation and inhibitory control.

Original languageEnglish (US)
Pages (from-to)800-806
Number of pages7
JournalKidney International
Volume87
Issue number4
DOIs
StatePublished - Apr 8 2015

Fingerprint

Executive Function
Chronic Renal Insufficiency
Pediatrics
Glomerular Filtration Rate
Wechsler Scales
Intelligence Tests
Premature Birth
North America
Intelligence
Siblings
Reference Values
Logistic Models
Odds Ratio
Mothers
Blood Pressure
Education
Population

Keywords

  • CKD
  • Conners' continuous performance test
  • Neurocognitive function
  • Renal disease

ASJC Scopus subject areas

  • Nephrology

Cite this

Mendley, S. R., Matheson, M. B., Shinnar, S., Lande, M. B., Gerson, A. C., Butler, R. W., ... Hooper, S. R. (2015). Duration of chronic kidney disease reduces attention and executive function in pediatric patients. Kidney International, 87(4), 800-806. https://doi.org/10.1038/ki.2014.323

Duration of chronic kidney disease reduces attention and executive function in pediatric patients. / Mendley, Susan R.; Matheson, Matthew B.; Shinnar, Shlomo; Lande, Marc B.; Gerson, Arlene C.; Butler, Robert W.; Warady, Bradley A.; Furth, Susan L.; Hooper, Stephen R.

In: Kidney International, Vol. 87, No. 4, 08.04.2015, p. 800-806.

Research output: Contribution to journalArticle

Mendley, SR, Matheson, MB, Shinnar, S, Lande, MB, Gerson, AC, Butler, RW, Warady, BA, Furth, SL & Hooper, SR 2015, 'Duration of chronic kidney disease reduces attention and executive function in pediatric patients', Kidney International, vol. 87, no. 4, pp. 800-806. https://doi.org/10.1038/ki.2014.323
Mendley, Susan R. ; Matheson, Matthew B. ; Shinnar, Shlomo ; Lande, Marc B. ; Gerson, Arlene C. ; Butler, Robert W. ; Warady, Bradley A. ; Furth, Susan L. ; Hooper, Stephen R. / Duration of chronic kidney disease reduces attention and executive function in pediatric patients. In: Kidney International. 2015 ; Vol. 87, No. 4. pp. 800-806.
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