Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia

Michael Mikulasovich, Amanda LeBlanc, Angela Scalise, Deepa G. Manwani, Alla Keyzner, Vesna Najfeld

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume188
Issue number2
DOIs
StatePublished - Jan 15 2009
Externally publishedYes

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Acute Myeloid Leukemia
Isochromosomes
Recurrence
Population

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia. / Mikulasovich, Michael; LeBlanc, Amanda; Scalise, Angela; Manwani, Deepa G.; Keyzner, Alla; Najfeld, Vesna.

In: Cancer Genetics and Cytogenetics, Vol. 188, No. 2, 15.01.2009, p. 83-87.

Research output: Contribution to journalArticle

Mikulasovich, Michael ; LeBlanc, Amanda ; Scalise, Angela ; Manwani, Deepa G. ; Keyzner, Alla ; Najfeld, Vesna. / Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia. In: Cancer Genetics and Cytogenetics. 2009 ; Vol. 188, No. 2. pp. 83-87.
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