TY - JOUR
T1 - Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia
AU - Mikulasovich, Michael
AU - LeBlanc, Amanda
AU - Scalise, Angela
AU - Manwani, Deepa
AU - Keyzner, Alla
AU - Najfeld, Vesna
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/1/15
Y1 - 2009/1/15
N2 - We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.
AB - We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse.
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U2 - 10.1016/j.cancergencyto.2008.10.004
DO - 10.1016/j.cancergencyto.2008.10.004
M3 - Article
C2 - 19100510
AN - SCOPUS:57549108489
SN - 0165-4608
VL - 188
SP - 83
EP - 87
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -