Duodenal-type follicular lymphoma a clinicopathologic review

Etan Marks, Yang Shi

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Duodenal-type follicular lymphoma (D-FL) is a newly recognized entity in the 2016 World Health Organization classification update. It has an immunophenotype similar to that of other FLs and usually carries the typical t(14;18)(q32;q21) translocation. However, unlike other FLs, D-FL is almost always diagnosed at a low stage and stays localized to the small intestine, most commonly the second portion of the duodenum, whereas the vast majority of other FLs are diagnosed at an advanced stage. Additionally, D-FL gene expression and pathogenesis appear to be more closely related to extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue than to other types of FL. Therefore, many oncologists have opted to treat this variant of FL in a "watch and wait" manner because of its excellent prognosis and the rarity of D-FL to progress even when no treatments are attempted.

Original languageEnglish (US)
Pages (from-to)542-547
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume142
Issue number4
DOIs
StatePublished - Apr 1 2018

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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