Duodenal Lipid Sensing Activates Vagal Afferents to Regulate Non-Shivering Brown Fat Thermogenesis in Rats

Clémence Blouet, Gary J. Schwartz

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Previous evidence indicates that duodenal lipid sensing engages gut-brain neurocircuits to determine food intake and hepatic glucose production, but a potential role for gut-brain communication in the control of energy expenditure remains to be determined. Here, we tested the hypothesis that duodenal lipid sensing activates a gut-brain-brown adipose tissue neuraxis to regulate thermogenesis. We demonstrate that direct administration of lipids into the duodenum increases brown fat temperature. Co-infusion of the local anesthetic tetracaine with duodenal lipids abolished the lipid-induced increase in brown fat temperature. Systemic administration of the CCKA receptor antagonist devazepide blocked the ability of duodenal lipids to increase brown fat thermogenesis. Parenchymal administration of the N-methyl-d-aspartate receptor blocker MK-801 directly into the caudomedial nucleus of the solitary tract also abolished duodenal lipid-induced activation of brown fat thermogenesis. These findings establish that duodenal lipid sensing activates a gut-brain-brown fat axis to determine brown fat temperature, and thereby reveal a previously unappreciated pathway that regulates thermogenesis.

Original languageEnglish (US)
Article numbere51898
JournalPLoS One
Volume7
Issue number12
DOIs
StatePublished - Dec 14 2012

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Brown Adipose Tissue
brown adipose tissue
Thermogenesis
heat production
Rats
Fats
Lipids
rats
lipids
Brain
digestive system
brain
Temperature
Devazepide
Tetracaine
local anesthetics
temperature
receptors
Solitary Nucleus
Aptitude

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Duodenal Lipid Sensing Activates Vagal Afferents to Regulate Non-Shivering Brown Fat Thermogenesis in Rats. / Blouet, Clémence; Schwartz, Gary J.

In: PLoS One, Vol. 7, No. 12, e51898, 14.12.2012.

Research output: Contribution to journalArticle

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