Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

Biwei Yin; Roman V. Kuranov; Austin B. McElroy; Shams Kazmi; Andrew K. Dunn; Timothy Q. Duong; Thomas E. Milner

doi:10.1117/1.JBO.18.5.056005

Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

Biwei Yin, Roman V. Kuranov, Austin B. McElroy, Shams Kazmi, Andrew K. Dunn, Timothy Q. Duong, Thomas E. Milner

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO₂) levels in phantom blood vessels with a range of blood flow speeds (0 to 17 mm/s). A 50-μm-diameter blood vessel phantom is imaged, and SO2 levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO₂ measurement are identified and investigated.

Original language	English (US)
Article number	056005
Journal	Journal of Biomedical Optics
Volume	18
Issue number	5
DOIs	https://doi.org/10.1117/1.JBO.18.5.056005
State	Published - May 2013
Externally published	Yes

Keywords

dual-wavelength
hemoglobin oxygen saturation
imaging
microvasculature
optical coherence tomography
phantom
phase-sensitive

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.JBO.18.5.056005

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title = "Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation",

abstract = "A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO2) levels in phantom blood vessels with a range of blood flow speeds (0 to 17 mm/s). A 50-μm-diameter blood vessel phantom is imaged, and SO2 levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO2 measurement are identified and investigated.",

keywords = "dual-wavelength, hemoglobin oxygen saturation, imaging, microvasculature, optical coherence tomography, phantom, phase-sensitive",

author = "Biwei Yin and Kuranov, {Roman V.} and McElroy, {Austin B.} and Shams Kazmi and Dunn, {Andrew K.} and Duong, {Timothy Q.} and Milner, {Thomas E.}",

note = "Funding Information: This study was partially supported by NIH KL2 training grants (Parent Grant Nos. UL1RR025767 and KL2RR025766); by the San Antonio Area Foundation (Grant No. 130977); and by research support from Carl Zeiss Meditec to RVK and TEM, from the Department of Veterans Affairs (VA MERIT Award) to TQD, and by the NIH (R01 EY018855 and R01 EY014211) to TQD. The authors also gratefully acknowledge support from the National Institutes of Health (NIH R01EY016462).",

year = "2013",

month = may,

doi = "10.1117/1.JBO.18.5.056005",

language = "English (US)",

volume = "18",

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AU - Yin, Biwei

AU - Kuranov, Roman V.

AU - McElroy, Austin B.

AU - Kazmi, Shams

AU - Dunn, Andrew K.

AU - Duong, Timothy Q.

AU - Milner, Thomas E.

N1 - Funding Information: This study was partially supported by NIH KL2 training grants (Parent Grant Nos. UL1RR025767 and KL2RR025766); by the San Antonio Area Foundation (Grant No. 130977); and by research support from Carl Zeiss Meditec to RVK and TEM, from the Department of Veterans Affairs (VA MERIT Award) to TQD, and by the NIH (R01 EY018855 and R01 EY014211) to TQD. The authors also gratefully acknowledge support from the National Institutes of Health (NIH R01EY016462).

PY - 2013/5

Y1 - 2013/5

N2 - A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO2) levels in phantom blood vessels with a range of blood flow speeds (0 to 17 mm/s). A 50-μm-diameter blood vessel phantom is imaged, and SO2 levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO2 measurement are identified and investigated.

AB - A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO2) levels in phantom blood vessels with a range of blood flow speeds (0 to 17 mm/s). A 50-μm-diameter blood vessel phantom is imaged, and SO2 levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO2 measurement are identified and investigated.

KW - dual-wavelength

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Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

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