Dual tracer stable isotopic assessment of calcium absorption and endogenous fecal excretion in low birth weight infants

Steven A. Abrams, Nora V. Esteban, Nancy E. Vieira, Alfred L. Yergey

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Using a dual tracer (44Ca orally and46Ca i.v.) stable isotope technique, true dietary Ca absorption, endogenous fecal Ca excretion, and net Ca retention were measured in 12 low birth weight (1426 ± 260 g) infants fed a high Ca-containing formula. Endogenous fecal Ca excretion averaged 7.2 ± 4.1% of intake, and exceeded 10% of intake in three infants. Net Ca retention, 103 ± 38 mg/kg/d, was consistent with previous studies of Ca retention obtained using mass balance techniques and correlated closely (r = 0.98, p < 0.001) with true Ca absorption but not with endogenous fecal excretion (r = — 0.40, p = 0.19). Although endogenous fecal excretion may represent a significant source of Ca loss for some low birth weight infants, these data suggest that net Ca retention in low birth weight infants fed a high Ca-containing formula is primarily determined by the total dietary Ca absorbed.

Original languageEnglish (US)
Pages (from-to)615-618
Number of pages4
JournalPediatric Research
Volume29
Issue number6
DOIs
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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