DTI parameter changes in axonal loss due to multiple sclerosis

A. Roceanu, M. Onu, V. Ferastraoaru, E. Tarta, F. Preoteasa, F. Antochi, O. Bajenaru

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Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system with presumed autoimmune origin. It is largely accepted that the inflammatory induced loss of axons and neurons is the underlying cause of disability in multiple sclerosis patients. Diffusion tensor imaging (DTI) is a new neuroimaging technique based on MRI, used for quantification of water diffusion in tissues. We performed DTI to 12 MS patients in order to assess idiffusion parameters (fractional anisotropy, mean diffusivity, longitudinal diffusivity (F1) and transversal diffusivities (F2, F3). We found that F1 may be used as an indicator of axonal loss in human as well, proving a good correlation with degree of disability.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalRomanian Journal of Neurology/ Revista Romana de Neurologie
Volume10
Issue number2
Publication statusPublished - Jan 1 2011

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Keywords

  • Axonal loss
  • Diffusion tensor imaging (DTI)
  • Disability
  • Multiple scleorsis (MS)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Roceanu, A., Onu, M., Ferastraoaru, V., Tarta, E., Preoteasa, F., Antochi, F., & Bajenaru, O. (2011). DTI parameter changes in axonal loss due to multiple sclerosis. Romanian Journal of Neurology/ Revista Romana de Neurologie, 10(2), 73-76.