Drug–nutrient interactions (DNIs) are on the increase in older adults due to high prevalence of polypharmacy, which presents an opportunity for drug interactions with nutrients. The impact and burden of DNIs in older adults are many, including morbidity, hospitalizations, and mortality. DNIs are contributary to adverse drug events. DNIs occur among a wide range of therapeutic classes. The risk factors contributing to DNIs, types of interactions, consequences, and examples of commonly used medications and herbal preparations and their interactions with nutrients are presented. Awareness of DNIs and proper drug selection offers opportunity for diagnosis and prevention.
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