Drug resistance in colon cancer

R. Gorlick, J. R. Bertino

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


A significant obstacle for the successful management of patients with colorectal cancer is intrinsic drug resistance or, in patients who respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a variety of mechanisms, including alterations in drug influx, drug efflux, intracellular metabolic activation, and intracellular catabolism, or through alterations in the drug's target. In addition, alterations in genes involved in the regulation of the cell cycle or in DNA damage repair may result in a cell becoming resistant to chemotherapy. In this chapter, the mechanisms of action and the mechanisms of resistance to the fluoropyrimidines and raltitrexed (Tomudex; Zeneca Pharmaceuticals, Wilmington, DE) are reviewed, focusing on newer studies using gastric and colorectal tumor samples obtained from patients. Clinical trials using this new information are anticipated.

Original languageEnglish (US)
Pages (from-to)606-611
Number of pages6
JournalSeminars in oncology
Issue number6
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology


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