Drug Metabolism as a Community Effort

R. Hitchings; Libusha Kelly

doi:10.1016/j.cmet.2019.07.005

Drug Metabolism as a Community Effort

R. Hitchings, Libusha Kelly

Systems & Computational Biology

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Levodopa (L-dopa) is the primary treatment for Parkinson's disease. The gut microbiome can metabolize levodopa, potentially leading to decreased efficacy and side effects, but responsible bacteria were unknown. Maini Rekdal et al. (2019) characterize enzymes in two gut bacteria that sequentially metabolize L-dopa and identify a novel inhibitor that may improve outcomes.

Original language	English (US)
Pages (from-to)	235-237
Number of pages	3
Journal	Cell metabolism
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2019.07.005
State	Published - Aug 6 2019

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2019.07.005

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title = "Drug Metabolism as a Community Effort",

abstract = "Levodopa (L-dopa) is the primary treatment for Parkinson's disease. The gut microbiome can metabolize levodopa, potentially leading to decreased efficacy and side effects, but responsible bacteria were unknown. Maini Rekdal et al. (2019) characterize enzymes in two gut bacteria that sequentially metabolize L-dopa and identify a novel inhibitor that may improve outcomes.",

author = "R. Hitchings and Libusha Kelly",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = aug,

day = "6",

doi = "10.1016/j.cmet.2019.07.005",

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T1 - Drug Metabolism as a Community Effort

AU - Hitchings, R.

AU - Kelly, Libusha

PY - 2019/8/6

Y1 - 2019/8/6

N2 - Levodopa (L-dopa) is the primary treatment for Parkinson's disease. The gut microbiome can metabolize levodopa, potentially leading to decreased efficacy and side effects, but responsible bacteria were unknown. Maini Rekdal et al. (2019) characterize enzymes in two gut bacteria that sequentially metabolize L-dopa and identify a novel inhibitor that may improve outcomes.

AB - Levodopa (L-dopa) is the primary treatment for Parkinson's disease. The gut microbiome can metabolize levodopa, potentially leading to decreased efficacy and side effects, but responsible bacteria were unknown. Maini Rekdal et al. (2019) characterize enzymes in two gut bacteria that sequentially metabolize L-dopa and identify a novel inhibitor that may improve outcomes.

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DO - 10.1016/j.cmet.2019.07.005

M3 - Short survey

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SN - 1550-4131

VL - 30

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JO - Cell metabolism

JF - Cell metabolism

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ER -

Drug Metabolism as a Community Effort

Abstract

ASJC Scopus subject areas

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