TY - JOUR
T1 - Drug-induced cutaneous vasculitis and anticoagulant-related cutaneous adverse reactions
T2 - insights in pathogenesis, clinical presentation, and treatment
AU - Guzman, Anthony K.
AU - Balagula, Yevgeniy
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Drug-induced vasculitis and anticoagulant-related skin reactions are commonly encountered in the inpatient and outpatient settings. The spectrum of clinical presentation is broad and ranges from focal, skin-limited disease, to more extensive cutaneous and soft tissue necrosis, to potentially fatal systemic involvement. The prompt recognition of these adverse events can have a significant impact on patient morbidity and mortality. We highlight the key features of the clinical presentation with an emphasis on primary lesion morphology, distribution, and epidemiology of purpuric drug reactions. The proposed pathophysiology, histologic findings, and therapeutic interventions of these potentially life-threatening diseases are discussed.
AB - Drug-induced vasculitis and anticoagulant-related skin reactions are commonly encountered in the inpatient and outpatient settings. The spectrum of clinical presentation is broad and ranges from focal, skin-limited disease, to more extensive cutaneous and soft tissue necrosis, to potentially fatal systemic involvement. The prompt recognition of these adverse events can have a significant impact on patient morbidity and mortality. We highlight the key features of the clinical presentation with an emphasis on primary lesion morphology, distribution, and epidemiology of purpuric drug reactions. The proposed pathophysiology, histologic findings, and therapeutic interventions of these potentially life-threatening diseases are discussed.
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U2 - 10.1016/j.clindermatol.2020.06.015
DO - 10.1016/j.clindermatol.2020.06.015
M3 - Article
AN - SCOPUS:85090486308
VL - 38
SP - 613
EP - 628
JO - Clinics in Dermatology
JF - Clinics in Dermatology
SN - 0738-081X
IS - 6
ER -