Doppler velocimetry in pregnant patients with sickle cell anemia

Henny H. Billett, O. Langer, O. T. Regan, Irwin R. Merkatz, A. Anyaegbunam

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Women with sickle cell anemia have an increased risk of bearing low-birth-weight (LBW) progeny. To establish prognostic indicators of neonatal ouctome, 15 women with sickle cell anemia were followed through their pregnancies with the use of umbilical and uterine Doppler flow velocimetry. The systolic/diastolic ratios obtained were correlated with neonatal birth weight, gestational age, and birth weight percentile. Pregravid hemoglobin levels, reticulocyte counts, dense cell numbers, precentage hemoglobin F, and indirect bilirubin and lactate dehydrogenase levels were also determined, and statistical analysis was performed to assess whether any of these parameters would be useful in conjunction with velocimetry. We report here that, in sickle cell anemia, prenatal umbilical and uterine Doppler velocimetry ratios correlate inversely and significantly with neonatal birth weight (P < 0.005 and P < 0.002, respectively). In addition, prenatal maternal HbF levels also correlate significantly with Doppler velocimetry readings, an independent indicator of LBW progeny. Neither pregravid hemoglobin levels nor dense cell concentration correlates with Doppler umbilical and uterine flow velocimetry ratios determined during pregnancy. Pregravid high levels of HbF and velocimetry readings may serve to delineate a subset of sickle cell patients who may have different requirements for prenatal care. The possible mechanism for the detrimental effects of increased levels of fetal hemoglobin has not been clearly established, but it may involve increased propensity for vasoocclusion due to the unique rheology of the human placenta.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalAmerican Journal of Hematology
Volume42
Issue number3
StatePublished - 1993

Fingerprint

Rheology
Sickle Cell Anemia
Umbilicus
Birth Weight
Fetal Hemoglobin
Low Birth Weight Infant
Reading
Hemoglobins
Reticulocyte Count
Pregnancy
Prenatal Care
L-Lactate Dehydrogenase
Bilirubin
Placenta
Gestational Age
Cell Count
Mothers

Keywords

  • HbF
  • HbSS
  • Low birth weight

ASJC Scopus subject areas

  • Hematology

Cite this

Doppler velocimetry in pregnant patients with sickle cell anemia. / Billett, Henny H.; Langer, O.; Regan, O. T.; Merkatz, Irwin R.; Anyaegbunam, A.

In: American Journal of Hematology, Vol. 42, No. 3, 1993, p. 305-308.

Research output: Contribution to journalArticle

Billett, HH, Langer, O, Regan, OT, Merkatz, IR & Anyaegbunam, A 1993, 'Doppler velocimetry in pregnant patients with sickle cell anemia', American Journal of Hematology, vol. 42, no. 3, pp. 305-308.
Billett, Henny H. ; Langer, O. ; Regan, O. T. ; Merkatz, Irwin R. ; Anyaegbunam, A. / Doppler velocimetry in pregnant patients with sickle cell anemia. In: American Journal of Hematology. 1993 ; Vol. 42, No. 3. pp. 305-308.
@article{d350aa0b2e6a42c0b2677e6db9fc73df,
title = "Doppler velocimetry in pregnant patients with sickle cell anemia",
abstract = "Women with sickle cell anemia have an increased risk of bearing low-birth-weight (LBW) progeny. To establish prognostic indicators of neonatal ouctome, 15 women with sickle cell anemia were followed through their pregnancies with the use of umbilical and uterine Doppler flow velocimetry. The systolic/diastolic ratios obtained were correlated with neonatal birth weight, gestational age, and birth weight percentile. Pregravid hemoglobin levels, reticulocyte counts, dense cell numbers, precentage hemoglobin F, and indirect bilirubin and lactate dehydrogenase levels were also determined, and statistical analysis was performed to assess whether any of these parameters would be useful in conjunction with velocimetry. We report here that, in sickle cell anemia, prenatal umbilical and uterine Doppler velocimetry ratios correlate inversely and significantly with neonatal birth weight (P < 0.005 and P < 0.002, respectively). In addition, prenatal maternal HbF levels also correlate significantly with Doppler velocimetry readings, an independent indicator of LBW progeny. Neither pregravid hemoglobin levels nor dense cell concentration correlates with Doppler umbilical and uterine flow velocimetry ratios determined during pregnancy. Pregravid high levels of HbF and velocimetry readings may serve to delineate a subset of sickle cell patients who may have different requirements for prenatal care. The possible mechanism for the detrimental effects of increased levels of fetal hemoglobin has not been clearly established, but it may involve increased propensity for vasoocclusion due to the unique rheology of the human placenta.",
keywords = "HbF, HbSS, Low birth weight",
author = "Billett, {Henny H.} and O. Langer and Regan, {O. T.} and Merkatz, {Irwin R.} and A. Anyaegbunam",
year = "1993",
language = "English (US)",
volume = "42",
pages = "305--308",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Doppler velocimetry in pregnant patients with sickle cell anemia

AU - Billett, Henny H.

AU - Langer, O.

AU - Regan, O. T.

AU - Merkatz, Irwin R.

AU - Anyaegbunam, A.

PY - 1993

Y1 - 1993

N2 - Women with sickle cell anemia have an increased risk of bearing low-birth-weight (LBW) progeny. To establish prognostic indicators of neonatal ouctome, 15 women with sickle cell anemia were followed through their pregnancies with the use of umbilical and uterine Doppler flow velocimetry. The systolic/diastolic ratios obtained were correlated with neonatal birth weight, gestational age, and birth weight percentile. Pregravid hemoglobin levels, reticulocyte counts, dense cell numbers, precentage hemoglobin F, and indirect bilirubin and lactate dehydrogenase levels were also determined, and statistical analysis was performed to assess whether any of these parameters would be useful in conjunction with velocimetry. We report here that, in sickle cell anemia, prenatal umbilical and uterine Doppler velocimetry ratios correlate inversely and significantly with neonatal birth weight (P < 0.005 and P < 0.002, respectively). In addition, prenatal maternal HbF levels also correlate significantly with Doppler velocimetry readings, an independent indicator of LBW progeny. Neither pregravid hemoglobin levels nor dense cell concentration correlates with Doppler umbilical and uterine flow velocimetry ratios determined during pregnancy. Pregravid high levels of HbF and velocimetry readings may serve to delineate a subset of sickle cell patients who may have different requirements for prenatal care. The possible mechanism for the detrimental effects of increased levels of fetal hemoglobin has not been clearly established, but it may involve increased propensity for vasoocclusion due to the unique rheology of the human placenta.

AB - Women with sickle cell anemia have an increased risk of bearing low-birth-weight (LBW) progeny. To establish prognostic indicators of neonatal ouctome, 15 women with sickle cell anemia were followed through their pregnancies with the use of umbilical and uterine Doppler flow velocimetry. The systolic/diastolic ratios obtained were correlated with neonatal birth weight, gestational age, and birth weight percentile. Pregravid hemoglobin levels, reticulocyte counts, dense cell numbers, precentage hemoglobin F, and indirect bilirubin and lactate dehydrogenase levels were also determined, and statistical analysis was performed to assess whether any of these parameters would be useful in conjunction with velocimetry. We report here that, in sickle cell anemia, prenatal umbilical and uterine Doppler velocimetry ratios correlate inversely and significantly with neonatal birth weight (P < 0.005 and P < 0.002, respectively). In addition, prenatal maternal HbF levels also correlate significantly with Doppler velocimetry readings, an independent indicator of LBW progeny. Neither pregravid hemoglobin levels nor dense cell concentration correlates with Doppler umbilical and uterine flow velocimetry ratios determined during pregnancy. Pregravid high levels of HbF and velocimetry readings may serve to delineate a subset of sickle cell patients who may have different requirements for prenatal care. The possible mechanism for the detrimental effects of increased levels of fetal hemoglobin has not been clearly established, but it may involve increased propensity for vasoocclusion due to the unique rheology of the human placenta.

KW - HbF

KW - HbSS

KW - Low birth weight

UR - http://www.scopus.com/inward/record.url?scp=0027513635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027513635&partnerID=8YFLogxK

M3 - Article

C2 - 7679883

AN - SCOPUS:0027513635

VL - 42

SP - 305

EP - 308

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 3

ER -