Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility

N. L. Greenberg, M. S. Firstenberg, P. L. Castro, M. Main, A. Travaglini, J. A. Odabashian, J. K. Drinko, L. L. Rodriguez, J. D. Thomas, Mario J. Garcia

Research output: Contribution to journalArticle

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Abstract

Background - Myocardial fiber strain is directly related to left ventricular (LV) contractility. Strain rate can be estimated as the spatial derivative of velocities (dV/ds) obtained by tissue Doppler echocardiography (TDE). The purposes of the study were (1) to determine whether TDE-derived strain rate may be used as a noninvasive, quantitative index of contractility and (2) to compare the relative accuracy of systolic strain rate against TDE velocities alone. Methods and Results - TDE color M-mode images of the interventricular septum were recorded from the apical 4-chamber view in 7 closed-chest anesthetized mongrel dogs during 5 different inotropic stages. Simultaneous LV volume and pressure were obtained with a combined conductance-high-fidelity pressure catheter. Peak elastance (Emax) was determined as the slope of end-systolic pressure-volume relationships during caval occlusion and was used as the gold standard of LV contractility. Peak systolic TDE myocardial velocities (Sm) and peak (ε′p) and mean (ε′m) strain rates obtained at the basal septum were compared against Emax by linear regression. Emax as well as TDE systolic indices increased during inotropic stimulation with dobutamine and decreased with the infusion of esmolol. A stronger association was found between Emax and ε′p (r=0.94, P<0.01, y=0.29x+0.46) and ε′m (r=0.88, P<0.01) than for Sm (r=0.75, P<0.01). Conclusions - TDE-derived ε′p and ε′m are strong noninvasive indices of LV contractility. These indices appear to be more reliable than Sm, perhaps by eliminating translational artifact.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalCirculation
Volume105
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Doppler Echocardiography
Doppler Color Echocardiography
Venae Cavae
Dobutamine
Ventricular Pressure
Artifacts
Linear Models
Thorax
Catheters
Dogs
Blood Pressure
Pressure

Keywords

  • Contractility
  • Echocardiography
  • Hemodynamics
  • Strain

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Greenberg, N. L., Firstenberg, M. S., Castro, P. L., Main, M., Travaglini, A., Odabashian, J. A., ... Garcia, M. J. (2002). Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility. Circulation, 105(1), 99-105. https://doi.org/10.1161/hc0102.101396

Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility. / Greenberg, N. L.; Firstenberg, M. S.; Castro, P. L.; Main, M.; Travaglini, A.; Odabashian, J. A.; Drinko, J. K.; Rodriguez, L. L.; Thomas, J. D.; Garcia, Mario J.

In: Circulation, Vol. 105, No. 1, 01.01.2002, p. 99-105.

Research output: Contribution to journalArticle

Greenberg, NL, Firstenberg, MS, Castro, PL, Main, M, Travaglini, A, Odabashian, JA, Drinko, JK, Rodriguez, LL, Thomas, JD & Garcia, MJ 2002, 'Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility', Circulation, vol. 105, no. 1, pp. 99-105. https://doi.org/10.1161/hc0102.101396
Greenberg NL, Firstenberg MS, Castro PL, Main M, Travaglini A, Odabashian JA et al. Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility. Circulation. 2002 Jan 1;105(1):99-105. https://doi.org/10.1161/hc0102.101396
Greenberg, N. L. ; Firstenberg, M. S. ; Castro, P. L. ; Main, M. ; Travaglini, A. ; Odabashian, J. A. ; Drinko, J. K. ; Rodriguez, L. L. ; Thomas, J. D. ; Garcia, Mario J. / Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility. In: Circulation. 2002 ; Vol. 105, No. 1. pp. 99-105.
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T1 - Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility

AU - Greenberg, N. L.

AU - Firstenberg, M. S.

AU - Castro, P. L.

AU - Main, M.

AU - Travaglini, A.

AU - Odabashian, J. A.

AU - Drinko, J. K.

AU - Rodriguez, L. L.

AU - Thomas, J. D.

AU - Garcia, Mario J.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Background - Myocardial fiber strain is directly related to left ventricular (LV) contractility. Strain rate can be estimated as the spatial derivative of velocities (dV/ds) obtained by tissue Doppler echocardiography (TDE). The purposes of the study were (1) to determine whether TDE-derived strain rate may be used as a noninvasive, quantitative index of contractility and (2) to compare the relative accuracy of systolic strain rate against TDE velocities alone. Methods and Results - TDE color M-mode images of the interventricular septum were recorded from the apical 4-chamber view in 7 closed-chest anesthetized mongrel dogs during 5 different inotropic stages. Simultaneous LV volume and pressure were obtained with a combined conductance-high-fidelity pressure catheter. Peak elastance (Emax) was determined as the slope of end-systolic pressure-volume relationships during caval occlusion and was used as the gold standard of LV contractility. Peak systolic TDE myocardial velocities (Sm) and peak (ε′p) and mean (ε′m) strain rates obtained at the basal septum were compared against Emax by linear regression. Emax as well as TDE systolic indices increased during inotropic stimulation with dobutamine and decreased with the infusion of esmolol. A stronger association was found between Emax and ε′p (r=0.94, P<0.01, y=0.29x+0.46) and ε′m (r=0.88, P<0.01) than for Sm (r=0.75, P<0.01). Conclusions - TDE-derived ε′p and ε′m are strong noninvasive indices of LV contractility. These indices appear to be more reliable than Sm, perhaps by eliminating translational artifact.

AB - Background - Myocardial fiber strain is directly related to left ventricular (LV) contractility. Strain rate can be estimated as the spatial derivative of velocities (dV/ds) obtained by tissue Doppler echocardiography (TDE). The purposes of the study were (1) to determine whether TDE-derived strain rate may be used as a noninvasive, quantitative index of contractility and (2) to compare the relative accuracy of systolic strain rate against TDE velocities alone. Methods and Results - TDE color M-mode images of the interventricular septum were recorded from the apical 4-chamber view in 7 closed-chest anesthetized mongrel dogs during 5 different inotropic stages. Simultaneous LV volume and pressure were obtained with a combined conductance-high-fidelity pressure catheter. Peak elastance (Emax) was determined as the slope of end-systolic pressure-volume relationships during caval occlusion and was used as the gold standard of LV contractility. Peak systolic TDE myocardial velocities (Sm) and peak (ε′p) and mean (ε′m) strain rates obtained at the basal septum were compared against Emax by linear regression. Emax as well as TDE systolic indices increased during inotropic stimulation with dobutamine and decreased with the infusion of esmolol. A stronger association was found between Emax and ε′p (r=0.94, P<0.01, y=0.29x+0.46) and ε′m (r=0.88, P<0.01) than for Sm (r=0.75, P<0.01). Conclusions - TDE-derived ε′p and ε′m are strong noninvasive indices of LV contractility. These indices appear to be more reliable than Sm, perhaps by eliminating translational artifact.

KW - Contractility

KW - Echocardiography

KW - Hemodynamics

KW - Strain

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