Does transrenal fixation of aortic endografts impair renal function?

Neal S. Cayne, Soo J. Rhee, Frank J. Veith, Evan C. Lipsitz, Takao Ohki, Nicholas J. Gargiulo, Manish Mehta, William D. Suggs, Reese A. Wain, Alla Rosenblit, Carlos Timaran

Research output: Contribution to journalArticle

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Abstract

Objectives: Transrenal fixation (TFX) of aortic endografts is thought to increase the risk for renal infarction and impaired renal function. We studied the late effects of TFX on renal function and perfusion. Methods: Of 189 patients with commercial aortic endografts, which we inserted between 1995 and 2002, we reviewed data for 130 patients (112 men, 18 women) with available creatinine (Cr) concentration and contrast enhanced computed tomography (CT) scans preoperatively and 1 to 97 months after the procedure. Of the 130 patients, 69 patients had TFX and 61 patients had infrarenal fixation (IFX). Both groups were physiologically comparable. Average age was 76 ± 8 years for patients with TFX and 75 ± 8 years for patients with IFX. Presence of renal infarct or renal artery occlusion was determined by nephrograms on serial contrast-enhanced CT scans. Results: Mean follow-up was 17 ± 16 months (range, 1-54 months) for TFX and 21 ± 21 months (range, 1-97 months) for IFX. Mean serum Cr concentration increased significantly during long-term follow-up in both groups (TFX, 1.3 ± 0.5 mg/dL to 1.5 ± 0.8 mg/dL, P < .01; IFX, 1.3 ± 0.7 mg/dL to 1.4 ± 0.8 mg/dL, P < .03). Creatinine clearance (CrCl) similarly decreased over long-term follow-up in both groups (TFX, 53.3 ± 17.7 mL/min/1.73 m2 to 47.9 ± 16.2 mL/min/1.73 m2, P < .01; IFX, 58.1 ± 22.7 mL/min/1.73 m2 to 53.1 ± 23.4 mL/min/1.73 m2, P < .02). There were no significant differences in the increase in Cr concentration (P = .19) or decrease in CrCl (P = .68) between TFX and IFX groups. Small renal infarcts were noted in four patients (5.8%) in the TFX group and one patient (1.6%) in the IFX group. No increase in Cr concentration or decrease in CrCl was noted in any patient with a renal infarct. Postoperative renal dysfunction developed in 7 of 69 patients (10.1%) in the TFX group and 7 of 61 patients (11.5%) in the IFX group. There were no statistically significant differences between groups with respect to number of patients with new renal infarcts (P = .37) or postoperative renal dysfunction (P = .81). Conclusion: There is a slight increase in serum Cr concentration and decrease in CrCl after aortic endografting. However, there was no significant difference in these changes between patients with TFX and IFX. Although TFX may produce a higher incidence of small renal infarcts, these do not impair renal function. Thus our midterm results suggest that TFX can be performed safely, with no greater change in renal function than observed after IFX.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalJournal of Vascular Surgery
Volume38
Issue number4
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Kidney
Creatinine
Tomography
Renal Artery
Serum
Infarction
Perfusion
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Cayne, N. S., Rhee, S. J., Veith, F. J., Lipsitz, E. C., Ohki, T., Gargiulo, N. J., ... Timaran, C. (2003). Does transrenal fixation of aortic endografts impair renal function? Journal of Vascular Surgery, 38(4), 639-644. https://doi.org/10.1016/S0741-5214(03)00932-7

Does transrenal fixation of aortic endografts impair renal function? / Cayne, Neal S.; Rhee, Soo J.; Veith, Frank J.; Lipsitz, Evan C.; Ohki, Takao; Gargiulo, Nicholas J.; Mehta, Manish; Suggs, William D.; Wain, Reese A.; Rosenblit, Alla; Timaran, Carlos.

In: Journal of Vascular Surgery, Vol. 38, No. 4, 10.2003, p. 639-644.

Research output: Contribution to journalArticle

Cayne, NS, Rhee, SJ, Veith, FJ, Lipsitz, EC, Ohki, T, Gargiulo, NJ, Mehta, M, Suggs, WD, Wain, RA, Rosenblit, A & Timaran, C 2003, 'Does transrenal fixation of aortic endografts impair renal function?', Journal of Vascular Surgery, vol. 38, no. 4, pp. 639-644. https://doi.org/10.1016/S0741-5214(03)00932-7
Cayne, Neal S. ; Rhee, Soo J. ; Veith, Frank J. ; Lipsitz, Evan C. ; Ohki, Takao ; Gargiulo, Nicholas J. ; Mehta, Manish ; Suggs, William D. ; Wain, Reese A. ; Rosenblit, Alla ; Timaran, Carlos. / Does transrenal fixation of aortic endografts impair renal function?. In: Journal of Vascular Surgery. 2003 ; Vol. 38, No. 4. pp. 639-644.
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title = "Does transrenal fixation of aortic endografts impair renal function?",
abstract = "Objectives: Transrenal fixation (TFX) of aortic endografts is thought to increase the risk for renal infarction and impaired renal function. We studied the late effects of TFX on renal function and perfusion. Methods: Of 189 patients with commercial aortic endografts, which we inserted between 1995 and 2002, we reviewed data for 130 patients (112 men, 18 women) with available creatinine (Cr) concentration and contrast enhanced computed tomography (CT) scans preoperatively and 1 to 97 months after the procedure. Of the 130 patients, 69 patients had TFX and 61 patients had infrarenal fixation (IFX). Both groups were physiologically comparable. Average age was 76 ± 8 years for patients with TFX and 75 ± 8 years for patients with IFX. Presence of renal infarct or renal artery occlusion was determined by nephrograms on serial contrast-enhanced CT scans. Results: Mean follow-up was 17 ± 16 months (range, 1-54 months) for TFX and 21 ± 21 months (range, 1-97 months) for IFX. Mean serum Cr concentration increased significantly during long-term follow-up in both groups (TFX, 1.3 ± 0.5 mg/dL to 1.5 ± 0.8 mg/dL, P < .01; IFX, 1.3 ± 0.7 mg/dL to 1.4 ± 0.8 mg/dL, P < .03). Creatinine clearance (CrCl) similarly decreased over long-term follow-up in both groups (TFX, 53.3 ± 17.7 mL/min/1.73 m2 to 47.9 ± 16.2 mL/min/1.73 m2, P < .01; IFX, 58.1 ± 22.7 mL/min/1.73 m2 to 53.1 ± 23.4 mL/min/1.73 m2, P < .02). There were no significant differences in the increase in Cr concentration (P = .19) or decrease in CrCl (P = .68) between TFX and IFX groups. Small renal infarcts were noted in four patients (5.8{\%}) in the TFX group and one patient (1.6{\%}) in the IFX group. No increase in Cr concentration or decrease in CrCl was noted in any patient with a renal infarct. Postoperative renal dysfunction developed in 7 of 69 patients (10.1{\%}) in the TFX group and 7 of 61 patients (11.5{\%}) in the IFX group. There were no statistically significant differences between groups with respect to number of patients with new renal infarcts (P = .37) or postoperative renal dysfunction (P = .81). Conclusion: There is a slight increase in serum Cr concentration and decrease in CrCl after aortic endografting. However, there was no significant difference in these changes between patients with TFX and IFX. Although TFX may produce a higher incidence of small renal infarcts, these do not impair renal function. Thus our midterm results suggest that TFX can be performed safely, with no greater change in renal function than observed after IFX.",
author = "Cayne, {Neal S.} and Rhee, {Soo J.} and Veith, {Frank J.} and Lipsitz, {Evan C.} and Takao Ohki and Gargiulo, {Nicholas J.} and Manish Mehta and Suggs, {William D.} and Wain, {Reese A.} and Alla Rosenblit and Carlos Timaran",
year = "2003",
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language = "English (US)",
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TY - JOUR

T1 - Does transrenal fixation of aortic endografts impair renal function?

AU - Cayne, Neal S.

AU - Rhee, Soo J.

AU - Veith, Frank J.

AU - Lipsitz, Evan C.

AU - Ohki, Takao

AU - Gargiulo, Nicholas J.

AU - Mehta, Manish

AU - Suggs, William D.

AU - Wain, Reese A.

AU - Rosenblit, Alla

AU - Timaran, Carlos

PY - 2003/10

Y1 - 2003/10

N2 - Objectives: Transrenal fixation (TFX) of aortic endografts is thought to increase the risk for renal infarction and impaired renal function. We studied the late effects of TFX on renal function and perfusion. Methods: Of 189 patients with commercial aortic endografts, which we inserted between 1995 and 2002, we reviewed data for 130 patients (112 men, 18 women) with available creatinine (Cr) concentration and contrast enhanced computed tomography (CT) scans preoperatively and 1 to 97 months after the procedure. Of the 130 patients, 69 patients had TFX and 61 patients had infrarenal fixation (IFX). Both groups were physiologically comparable. Average age was 76 ± 8 years for patients with TFX and 75 ± 8 years for patients with IFX. Presence of renal infarct or renal artery occlusion was determined by nephrograms on serial contrast-enhanced CT scans. Results: Mean follow-up was 17 ± 16 months (range, 1-54 months) for TFX and 21 ± 21 months (range, 1-97 months) for IFX. Mean serum Cr concentration increased significantly during long-term follow-up in both groups (TFX, 1.3 ± 0.5 mg/dL to 1.5 ± 0.8 mg/dL, P < .01; IFX, 1.3 ± 0.7 mg/dL to 1.4 ± 0.8 mg/dL, P < .03). Creatinine clearance (CrCl) similarly decreased over long-term follow-up in both groups (TFX, 53.3 ± 17.7 mL/min/1.73 m2 to 47.9 ± 16.2 mL/min/1.73 m2, P < .01; IFX, 58.1 ± 22.7 mL/min/1.73 m2 to 53.1 ± 23.4 mL/min/1.73 m2, P < .02). There were no significant differences in the increase in Cr concentration (P = .19) or decrease in CrCl (P = .68) between TFX and IFX groups. Small renal infarcts were noted in four patients (5.8%) in the TFX group and one patient (1.6%) in the IFX group. No increase in Cr concentration or decrease in CrCl was noted in any patient with a renal infarct. Postoperative renal dysfunction developed in 7 of 69 patients (10.1%) in the TFX group and 7 of 61 patients (11.5%) in the IFX group. There were no statistically significant differences between groups with respect to number of patients with new renal infarcts (P = .37) or postoperative renal dysfunction (P = .81). Conclusion: There is a slight increase in serum Cr concentration and decrease in CrCl after aortic endografting. However, there was no significant difference in these changes between patients with TFX and IFX. Although TFX may produce a higher incidence of small renal infarcts, these do not impair renal function. Thus our midterm results suggest that TFX can be performed safely, with no greater change in renal function than observed after IFX.

AB - Objectives: Transrenal fixation (TFX) of aortic endografts is thought to increase the risk for renal infarction and impaired renal function. We studied the late effects of TFX on renal function and perfusion. Methods: Of 189 patients with commercial aortic endografts, which we inserted between 1995 and 2002, we reviewed data for 130 patients (112 men, 18 women) with available creatinine (Cr) concentration and contrast enhanced computed tomography (CT) scans preoperatively and 1 to 97 months after the procedure. Of the 130 patients, 69 patients had TFX and 61 patients had infrarenal fixation (IFX). Both groups were physiologically comparable. Average age was 76 ± 8 years for patients with TFX and 75 ± 8 years for patients with IFX. Presence of renal infarct or renal artery occlusion was determined by nephrograms on serial contrast-enhanced CT scans. Results: Mean follow-up was 17 ± 16 months (range, 1-54 months) for TFX and 21 ± 21 months (range, 1-97 months) for IFX. Mean serum Cr concentration increased significantly during long-term follow-up in both groups (TFX, 1.3 ± 0.5 mg/dL to 1.5 ± 0.8 mg/dL, P < .01; IFX, 1.3 ± 0.7 mg/dL to 1.4 ± 0.8 mg/dL, P < .03). Creatinine clearance (CrCl) similarly decreased over long-term follow-up in both groups (TFX, 53.3 ± 17.7 mL/min/1.73 m2 to 47.9 ± 16.2 mL/min/1.73 m2, P < .01; IFX, 58.1 ± 22.7 mL/min/1.73 m2 to 53.1 ± 23.4 mL/min/1.73 m2, P < .02). There were no significant differences in the increase in Cr concentration (P = .19) or decrease in CrCl (P = .68) between TFX and IFX groups. Small renal infarcts were noted in four patients (5.8%) in the TFX group and one patient (1.6%) in the IFX group. No increase in Cr concentration or decrease in CrCl was noted in any patient with a renal infarct. Postoperative renal dysfunction developed in 7 of 69 patients (10.1%) in the TFX group and 7 of 61 patients (11.5%) in the IFX group. There were no statistically significant differences between groups with respect to number of patients with new renal infarcts (P = .37) or postoperative renal dysfunction (P = .81). Conclusion: There is a slight increase in serum Cr concentration and decrease in CrCl after aortic endografting. However, there was no significant difference in these changes between patients with TFX and IFX. Although TFX may produce a higher incidence of small renal infarcts, these do not impair renal function. Thus our midterm results suggest that TFX can be performed safely, with no greater change in renal function than observed after IFX.

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