Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study

Luigi Di Biase, Pasquale Santangeli, Matteo Anselmino, Prasant Mohanty, Ilaria Salvetti, Sebastiano Gili, Rodney Horton, Javier E. Sanchez, Rong Bai, Sanghamitra Mohanty, Agnes Pump, Mauricio Cereceda Brantes, G. Joseph Gallinghouse, J. David Burkhardt, Federico Cesarani, Marco Scaglione, Andrea Natale, Fiorenzo Gaita

Research output: Contribution to journalArticle

335 Citations (Scopus)

Abstract

Objectives: This study investigated the left atrial appendage (LAA) by computed tomography (CT) and magnetic resonance imaging (MRI) to categorize different LAA morphologies and to correlate the morphology with the history of stroke/transient ischemic attack (TIA). Background: LAA represents one of the major sources of cardiac thrombus formation responsible for TIA/stroke in patients with atrial fibrillation (AF). Methods: We studied 932 patients with drug-refractory AF who were planning to undergo catheter ablation. All patients underwent cardiac CT or MRI of the LAA and were screened for history of TIA/stroke. Four different morphologies were used to categorize LAA: Cactus, Chicken Wing, Windsock, and Cauliflower. Results: CT scans of 499 patients and MRI scans of 433 patients were analyzed (age 59 ± 10 years, 79% were male, and 14% had CHADS 2 [Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack] score <2). The distribution of different LAA morphologies was Cactus (278 [30%]), Chicken Wing (451 [48%]), Windsock (179 [19%]), and Cauliflower (24 [3%]). Of the 932 patients, 78 (8%) had a history of ischemic stroke or TIA. The prevalence of pre-procedure stroke/TIA in Cactus, Chicken Wing, Windsock, and Cauliflower morphologies was 12%, 4%, 10%, and 18%, respectively (p = 0.003). After controlling for CHADS 2 score, gender, and AF types in a multivariable logistic model, Chicken Wing morphology was found to be 79% less likely to have a stroke/TIA history (odd ratio: 0.21, 95% confidence interval: 0.05 to 0.91, p = 0.036). In a separate multivariate model, we entered Chicken Wing as the reference group and assessed the likelihood of stroke in other groups in relation to reference. Compared with Chicken Wing, Cactus was 4.08 times (p = 0.046), Windsock was 4.5 times (p = 0.038), and Cauliflower was 8.0 times (p = 0.056) more likely to have had a stroke/TIA. Conclusions: Patients with Chicken Wing LAA morphology are less likely to have an embolic event even after controlling for comorbidities and CHADS 2 score. If confirmed, these results could have a relevant impact on the anticoagulation management of patients with a low-intermediate risk for stroke/TIA.

Original languageEnglish (US)
Pages (from-to)531-538
Number of pages8
JournalJournal of the American College of Cardiology
Volume60
Issue number6
DOIs
StatePublished - Aug 7 2012
Externally publishedYes

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Atrial Appendage
Transient Ischemic Attack
Atrial Fibrillation
Multicenter Studies
Stroke
Chickens
Cactaceae
Brassica
Tomography
Magnetic Resonance Imaging
Catheter Ablation
Comorbidity
Diabetes Mellitus
Thrombosis
Heart Failure
Logistic Models
History
Odds Ratio
Confidence Intervals
Hypertension

Keywords

  • CHADS score
  • left atrial appendage
  • stroke
  • stroke prevention
  • TIA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. / Di Biase, Luigi; Santangeli, Pasquale; Anselmino, Matteo; Mohanty, Prasant; Salvetti, Ilaria; Gili, Sebastiano; Horton, Rodney; Sanchez, Javier E.; Bai, Rong; Mohanty, Sanghamitra; Pump, Agnes; Cereceda Brantes, Mauricio; Gallinghouse, G. Joseph; Burkhardt, J. David; Cesarani, Federico; Scaglione, Marco; Natale, Andrea; Gaita, Fiorenzo.

In: Journal of the American College of Cardiology, Vol. 60, No. 6, 07.08.2012, p. 531-538.

Research output: Contribution to journalArticle

Di Biase, L, Santangeli, P, Anselmino, M, Mohanty, P, Salvetti, I, Gili, S, Horton, R, Sanchez, JE, Bai, R, Mohanty, S, Pump, A, Cereceda Brantes, M, Gallinghouse, GJ, Burkhardt, JD, Cesarani, F, Scaglione, M, Natale, A & Gaita, F 2012, 'Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study', Journal of the American College of Cardiology, vol. 60, no. 6, pp. 531-538. https://doi.org/10.1016/j.jacc.2012.04.032
Di Biase, Luigi ; Santangeli, Pasquale ; Anselmino, Matteo ; Mohanty, Prasant ; Salvetti, Ilaria ; Gili, Sebastiano ; Horton, Rodney ; Sanchez, Javier E. ; Bai, Rong ; Mohanty, Sanghamitra ; Pump, Agnes ; Cereceda Brantes, Mauricio ; Gallinghouse, G. Joseph ; Burkhardt, J. David ; Cesarani, Federico ; Scaglione, Marco ; Natale, Andrea ; Gaita, Fiorenzo. / Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. In: Journal of the American College of Cardiology. 2012 ; Vol. 60, No. 6. pp. 531-538.
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abstract = "Objectives: This study investigated the left atrial appendage (LAA) by computed tomography (CT) and magnetic resonance imaging (MRI) to categorize different LAA morphologies and to correlate the morphology with the history of stroke/transient ischemic attack (TIA). Background: LAA represents one of the major sources of cardiac thrombus formation responsible for TIA/stroke in patients with atrial fibrillation (AF). Methods: We studied 932 patients with drug-refractory AF who were planning to undergo catheter ablation. All patients underwent cardiac CT or MRI of the LAA and were screened for history of TIA/stroke. Four different morphologies were used to categorize LAA: Cactus, Chicken Wing, Windsock, and Cauliflower. Results: CT scans of 499 patients and MRI scans of 433 patients were analyzed (age 59 ± 10 years, 79{\%} were male, and 14{\%} had CHADS 2 [Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack] score <2). The distribution of different LAA morphologies was Cactus (278 [30{\%}]), Chicken Wing (451 [48{\%}]), Windsock (179 [19{\%}]), and Cauliflower (24 [3{\%}]). Of the 932 patients, 78 (8{\%}) had a history of ischemic stroke or TIA. The prevalence of pre-procedure stroke/TIA in Cactus, Chicken Wing, Windsock, and Cauliflower morphologies was 12{\%}, 4{\%}, 10{\%}, and 18{\%}, respectively (p = 0.003). After controlling for CHADS 2 score, gender, and AF types in a multivariable logistic model, Chicken Wing morphology was found to be 79{\%} less likely to have a stroke/TIA history (odd ratio: 0.21, 95{\%} confidence interval: 0.05 to 0.91, p = 0.036). In a separate multivariate model, we entered Chicken Wing as the reference group and assessed the likelihood of stroke in other groups in relation to reference. Compared with Chicken Wing, Cactus was 4.08 times (p = 0.046), Windsock was 4.5 times (p = 0.038), and Cauliflower was 8.0 times (p = 0.056) more likely to have had a stroke/TIA. Conclusions: Patients with Chicken Wing LAA morphology are less likely to have an embolic event even after controlling for comorbidities and CHADS 2 score. If confirmed, these results could have a relevant impact on the anticoagulation management of patients with a low-intermediate risk for stroke/TIA.",
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TY - JOUR

T1 - Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study

AU - Di Biase, Luigi

AU - Santangeli, Pasquale

AU - Anselmino, Matteo

AU - Mohanty, Prasant

AU - Salvetti, Ilaria

AU - Gili, Sebastiano

AU - Horton, Rodney

AU - Sanchez, Javier E.

AU - Bai, Rong

AU - Mohanty, Sanghamitra

AU - Pump, Agnes

AU - Cereceda Brantes, Mauricio

AU - Gallinghouse, G. Joseph

AU - Burkhardt, J. David

AU - Cesarani, Federico

AU - Scaglione, Marco

AU - Natale, Andrea

AU - Gaita, Fiorenzo

PY - 2012/8/7

Y1 - 2012/8/7

N2 - Objectives: This study investigated the left atrial appendage (LAA) by computed tomography (CT) and magnetic resonance imaging (MRI) to categorize different LAA morphologies and to correlate the morphology with the history of stroke/transient ischemic attack (TIA). Background: LAA represents one of the major sources of cardiac thrombus formation responsible for TIA/stroke in patients with atrial fibrillation (AF). Methods: We studied 932 patients with drug-refractory AF who were planning to undergo catheter ablation. All patients underwent cardiac CT or MRI of the LAA and were screened for history of TIA/stroke. Four different morphologies were used to categorize LAA: Cactus, Chicken Wing, Windsock, and Cauliflower. Results: CT scans of 499 patients and MRI scans of 433 patients were analyzed (age 59 ± 10 years, 79% were male, and 14% had CHADS 2 [Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack] score <2). The distribution of different LAA morphologies was Cactus (278 [30%]), Chicken Wing (451 [48%]), Windsock (179 [19%]), and Cauliflower (24 [3%]). Of the 932 patients, 78 (8%) had a history of ischemic stroke or TIA. The prevalence of pre-procedure stroke/TIA in Cactus, Chicken Wing, Windsock, and Cauliflower morphologies was 12%, 4%, 10%, and 18%, respectively (p = 0.003). After controlling for CHADS 2 score, gender, and AF types in a multivariable logistic model, Chicken Wing morphology was found to be 79% less likely to have a stroke/TIA history (odd ratio: 0.21, 95% confidence interval: 0.05 to 0.91, p = 0.036). In a separate multivariate model, we entered Chicken Wing as the reference group and assessed the likelihood of stroke in other groups in relation to reference. Compared with Chicken Wing, Cactus was 4.08 times (p = 0.046), Windsock was 4.5 times (p = 0.038), and Cauliflower was 8.0 times (p = 0.056) more likely to have had a stroke/TIA. Conclusions: Patients with Chicken Wing LAA morphology are less likely to have an embolic event even after controlling for comorbidities and CHADS 2 score. If confirmed, these results could have a relevant impact on the anticoagulation management of patients with a low-intermediate risk for stroke/TIA.

AB - Objectives: This study investigated the left atrial appendage (LAA) by computed tomography (CT) and magnetic resonance imaging (MRI) to categorize different LAA morphologies and to correlate the morphology with the history of stroke/transient ischemic attack (TIA). Background: LAA represents one of the major sources of cardiac thrombus formation responsible for TIA/stroke in patients with atrial fibrillation (AF). Methods: We studied 932 patients with drug-refractory AF who were planning to undergo catheter ablation. All patients underwent cardiac CT or MRI of the LAA and were screened for history of TIA/stroke. Four different morphologies were used to categorize LAA: Cactus, Chicken Wing, Windsock, and Cauliflower. Results: CT scans of 499 patients and MRI scans of 433 patients were analyzed (age 59 ± 10 years, 79% were male, and 14% had CHADS 2 [Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack] score <2). The distribution of different LAA morphologies was Cactus (278 [30%]), Chicken Wing (451 [48%]), Windsock (179 [19%]), and Cauliflower (24 [3%]). Of the 932 patients, 78 (8%) had a history of ischemic stroke or TIA. The prevalence of pre-procedure stroke/TIA in Cactus, Chicken Wing, Windsock, and Cauliflower morphologies was 12%, 4%, 10%, and 18%, respectively (p = 0.003). After controlling for CHADS 2 score, gender, and AF types in a multivariable logistic model, Chicken Wing morphology was found to be 79% less likely to have a stroke/TIA history (odd ratio: 0.21, 95% confidence interval: 0.05 to 0.91, p = 0.036). In a separate multivariate model, we entered Chicken Wing as the reference group and assessed the likelihood of stroke in other groups in relation to reference. Compared with Chicken Wing, Cactus was 4.08 times (p = 0.046), Windsock was 4.5 times (p = 0.038), and Cauliflower was 8.0 times (p = 0.056) more likely to have had a stroke/TIA. Conclusions: Patients with Chicken Wing LAA morphology are less likely to have an embolic event even after controlling for comorbidities and CHADS 2 score. If confirmed, these results could have a relevant impact on the anticoagulation management of patients with a low-intermediate risk for stroke/TIA.

KW - CHADS score

KW - left atrial appendage

KW - stroke

KW - stroke prevention

KW - TIA

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