TY - JOUR
T1 - Does the CD33 rs3865444 Polymorphism Confer Susceptibility to Alzheimer’s Disease?
AU - Siokas, Vasileios
AU - Aslanidou, Paraskevi
AU - Aloizou, Athina Maria
AU - Peristeri, Eleni
AU - Stamati, Polyxeni
AU - Liampas, Ioannis
AU - Arseniou, Stylianos
AU - Drakoulis, Nikolaos
AU - Aschner, Michael
AU - Tsatsakis, Aristidis
AU - Mitsias, Panayiotis D.
AU - Bogdanos, Dimitrios P.
AU - Hadjigeorgiou, Georgios M.
AU - Dardiotis, Efthimios
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Alzheimer’s disease (AD) is a complex genetic disorder. To date, published data have reported conflicting results on the role of CD33 rs3865444 polymorphism in AD. The present study aimed at evaluating the effect of rs3865444 on AD in a large cohort of Greek native patients with AD. We also conducted a meta-analysis by pooling information from different studies on the same topic. Patients with AD (n = 327) and healthy controls (n = 327) were analyzed and genotyped for rs3865444. Single locus analyses were run to explore possible associations between CD33 rs3865444 polymorphism and AD. Our analysis yielded no significant interaction between AD and the CD33 rs3865444 polymorphism. The lack of interaction between the two variables persisted even after a pooled meta-analysis of 8 studies (with 13 datasets), with 4015 AD cases and 7981 controls. The overall results do not support the hypothesis that CD33 rs3865444 polymorphism increases the risk of AD. The results also suggest that the identification of functional variants in CD33 that are indisputably correlated with AD may be an important factor to investigate in future genetic screening studies.
AB - Alzheimer’s disease (AD) is a complex genetic disorder. To date, published data have reported conflicting results on the role of CD33 rs3865444 polymorphism in AD. The present study aimed at evaluating the effect of rs3865444 on AD in a large cohort of Greek native patients with AD. We also conducted a meta-analysis by pooling information from different studies on the same topic. Patients with AD (n = 327) and healthy controls (n = 327) were analyzed and genotyped for rs3865444. Single locus analyses were run to explore possible associations between CD33 rs3865444 polymorphism and AD. Our analysis yielded no significant interaction between AD and the CD33 rs3865444 polymorphism. The lack of interaction between the two variables persisted even after a pooled meta-analysis of 8 studies (with 13 datasets), with 4015 AD cases and 7981 controls. The overall results do not support the hypothesis that CD33 rs3865444 polymorphism increases the risk of AD. The results also suggest that the identification of functional variants in CD33 that are indisputably correlated with AD may be an important factor to investigate in future genetic screening studies.
KW - AD
KW - CD33
KW - Genetics
KW - Polymorphism
KW - SNPs
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U2 - 10.1007/s12031-020-01507-w
DO - 10.1007/s12031-020-01507-w
M3 - Article
C2 - 32088842
AN - SCOPUS:85079793851
SN - 0895-8696
VL - 70
SP - 851
EP - 860
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
IS - 6
ER -