Does the bioavailability of β-Carotene (β-C) change with aging?

E. P. Norkus, R. O. Russell, Madhusudhana R. Kanagala, Z. Asfaw, Rajendran, J. Sawhney, Thiruvinvamalai S. Dharmarajan

Research output: Contribution to journalArticle

Abstract

Recently, we presented data that suggested a negative relationship between daily use of multivitamins (containing β-C) and serum β-C values in the elderly. The present study compared the relative bioavailability of β-C between elderly (E) and non-elderly (NE) subjects during a 14-day β-C supplementation trial (1 x 15 mg OTC capsule of β-C /day). Prior to supplementation, the 9 E subjects (75 ± 4 yr. 4 females & 5 males) and 20 NE subjects (34 ± 8 yr, 10 females & 10 males) had statistically similar serum β-C levels [15.1 ± 0.8 (SD) μg/dL for NE vs. 16.3 ± 1.2 (SD) μg/dL for E]. β-C supplementation significantly raised fasting serum β-C levels (P<0.0001) in both NE and E volunteers. Following β-C supplementation, no significant difference in mean serum values, absolute change in serum level, percent change in serum level, area under the serum curve (AUC), expressed as AUC or AUC standardized by body mass index, body fat, or lean body mass was observed between the NE and E volunteers. These findings suggest that β-C bioavailability is not impaired in healthy, cognitively normal, community elderly compared to younger adults. Aging, per se, does not appear to alter bioavailability of β-C in the healthy individual.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998
Externally publishedYes

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Carotenoids
carotenes
Biological Availability
bioavailability
Aging of materials
volunteers
Serum
lean body mass
young adults
body fat
Area Under Curve
Capsules
fasting
body mass index
Fats
Volunteers
Adipose Tissue
Young Adult
Fasting
Body Mass Index

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Norkus, E. P., Russell, R. O., Kanagala, M. R., Asfaw, Z., Rajendran, Sawhney, J., & Dharmarajan, T. S. (1998). Does the bioavailability of β-Carotene (β-C) change with aging? FASEB Journal, 12(5).

Does the bioavailability of β-Carotene (β-C) change with aging? / Norkus, E. P.; Russell, R. O.; Kanagala, Madhusudhana R.; Asfaw, Z.; Rajendran; Sawhney, J.; Dharmarajan, Thiruvinvamalai S.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

Norkus, EP, Russell, RO, Kanagala, MR, Asfaw, Z, Rajendran, Sawhney, J & Dharmarajan, TS 1998, 'Does the bioavailability of β-Carotene (β-C) change with aging?', FASEB Journal, vol. 12, no. 5.
Norkus EP, Russell RO, Kanagala MR, Asfaw Z, Rajendran, Sawhney J et al. Does the bioavailability of β-Carotene (β-C) change with aging? FASEB Journal. 1998 Mar 20;12(5).
Norkus, E. P. ; Russell, R. O. ; Kanagala, Madhusudhana R. ; Asfaw, Z. ; Rajendran ; Sawhney, J. ; Dharmarajan, Thiruvinvamalai S. / Does the bioavailability of β-Carotene (β-C) change with aging?. In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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