Docetaxel Plus Cisplatin: An Active Combination Regimen in Non-Small-Cell Lung Cancer

Richard J. Gralla, John T. Cole, Carrie N. Robertson, Carol B. Marques, Cynthia N. Rittenberg

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Abstract

Docetaxel (Taxotere) is a semisynthetic taxoid that possesses significant activity as a single agent in the treatment of patients with non-small-cell lung cancer. In patients with advanced non-small-cell lung cancer who had previously failed cisplatin (Platinol)-based chemotherapy, 100 mg/m2 of docetaxel administered as an intravenous infusion over 1 hour, once every 3 weeks, produced a median response rate of 17% (of the intent-to-treat population) and median survival of 9 months. The present report describes the preliminary results from 3 phase II trials performed in the United States, France, and Australia, examining the combination of docetaxel and cisplatin in patients with advanced non-small-cell lung cancer. One trial (Australian) studied docetaxel administered as a 1-hour intravenous infusion followed by a 30-minute infusion of cisplatin on days 1, 22, and then every 3 weeks. The French and US trials administered docetaxel every 3 weeks, but gave cisplatin on days 1, 22, and then every 6 weeks. Major response rates ranged from 30% to 51% and median estimated survival ranged from 9 to 10.5 months. Based on the results of these trials, the recommended dose for future phase II and III trials in patients with advanced non-small-cell lung cancer is either 75 mg/m2 of docetaxel and 75 mg/m2 of cisplatin, or 65 mg/m2 of docetaxel and 100 mg/m2 of cisplatin, with docetaxel being administered once every 3 weeks and cisplatin on days 1, 22, and then every 6 weeks.

Original languageEnglish (US)
Pages (from-to)27-30
Number of pages4
JournalONCOLOGY
Volume11
Issue number7 SUPPL.
Publication statusPublished - Dec 1 1997

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Docetaxel Plus Cisplatin : An Active Combination Regimen in Non-Small-Cell Lung Cancer. / Gralla, Richard J.; Cole, John T.; Robertson, Carrie N.; Marques, Carol B.; Rittenberg, Cynthia N.

In: ONCOLOGY, Vol. 11, No. 7 SUPPL., 01.12.1997, p. 27-30.

Research output: Contribution to journalArticle