Do shared HLA antigens between present and past donors adversely affect graft survival in recipients with a past positive donor crossmatch?

We identified a subgroup of recipients undergoing retransplantation whose present donor's HLA antigens matched at least in part those of their previous donor(s). We studied whether or not the sharing of HLA antigen(s) between the present and previous allograft donors adversely affects allograft survival in those recipients with a positive NCS donor-specific XM. Graft survival for primary and retransplants in patients with a posistive NCS donor-specific XM was not significantly different. In addition, in patients undergoing retransplantation with a positive NCS donor-specific XM whose donor(s) shared HLA antigen(s), the 1-year graft survival was not adversely affected.