DNA repair in relation to the aging process

Jan Vijg, D. L. Knook

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

On the basis of the presently available data on the activities of the complex DNA repair systems in mammalian cells, it is not possible to draw definite conclusions with respect to any relationship of DNA repair with the aging process. This certainly does not imply that DNA repair has no significance for the aging process. On the contrary, both cancer and immunological defects, the incidences of which increase greatly with age, are associated with deficiencies in certain DNA repair pathways. In addition, there is evidence that a DNA repair defect is associated with Alzheimer's disease and Parkinson's disease. It seems important to obtain more insight into the nature of such phenomena. However, before any realistic conclusions can be drawn with some relevance to aging it is necessary to assess DNA repair activities in various organs and tissues during aging of individual animals (of different species), in relation to the amount of accumulated DNA damage and the frequency and nature of DNA sequence changes.

Original languageEnglish (US)
Pages (from-to)532-541
Number of pages10
JournalJournal of the American Geriatrics Society
Volume35
Issue number6
StatePublished - 1987
Externally publishedYes

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DNA Repair
DNA Damage
Parkinson Disease
Alzheimer Disease
Incidence
Neoplasms

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

DNA repair in relation to the aging process. / Vijg, Jan; Knook, D. L.

In: Journal of the American Geriatrics Society, Vol. 35, No. 6, 1987, p. 532-541.

Research output: Contribution to journalArticle

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