DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis

Giulia Orsatti, Pietra D. Greenberg, Donald B. Rolfes, Kamal G. Ishak, Fiorenzo Paronetto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

Original languageEnglish (US)
Pages (from-to)936-939
Number of pages4
JournalHuman Pathology
Volume25
Issue number9
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Ploidies
DNA
Tetraploidy
Aneuploidy
Diploidy
Neoplasms
Carcinoma
Liver
Fibrolamellar hepatocellular carcinoma

Keywords

  • DNA ploidy
  • fibrolamellar carcinoma
  • hepatocellular carcinoma
  • nuclear DNA content

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Orsatti, G., Greenberg, P. D., Rolfes, D. B., Ishak, K. G., & Paronetto, F. (1994). DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis. Human Pathology, 25(9), 936-939. https://doi.org/10.1016/0046-8177(94)90015-9

DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis. / Orsatti, Giulia; Greenberg, Pietra D.; Rolfes, Donald B.; Ishak, Kamal G.; Paronetto, Fiorenzo.

In: Human Pathology, Vol. 25, No. 9, 1994, p. 936-939.

Research output: Contribution to journalArticle

Orsatti, G, Greenberg, PD, Rolfes, DB, Ishak, KG & Paronetto, F 1994, 'DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis', Human Pathology, vol. 25, no. 9, pp. 936-939. https://doi.org/10.1016/0046-8177(94)90015-9
Orsatti, Giulia ; Greenberg, Pietra D. ; Rolfes, Donald B. ; Ishak, Kamal G. ; Paronetto, Fiorenzo. / DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis. In: Human Pathology. 1994 ; Vol. 25, No. 9. pp. 936-939.
@article{049f15c2ca6f40a585f86c3d5a7ba6bd,
title = "DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis",
abstract = "Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.",
keywords = "DNA ploidy, fibrolamellar carcinoma, hepatocellular carcinoma, nuclear DNA content",
author = "Giulia Orsatti and Greenberg, {Pietra D.} and Rolfes, {Donald B.} and Ishak, {Kamal G.} and Fiorenzo Paronetto",
year = "1994",
doi = "10.1016/0046-8177(94)90015-9",
language = "English (US)",
volume = "25",
pages = "936--939",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis

AU - Orsatti, Giulia

AU - Greenberg, Pietra D.

AU - Rolfes, Donald B.

AU - Ishak, Kamal G.

AU - Paronetto, Fiorenzo

PY - 1994

Y1 - 1994

N2 - Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

AB - Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgenstained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 μm2 ± 18.0; mean ± standard deviation) was significantly larger than that of the surrounding noncancerous livers (33.2 ± 4.7; P < .0001). These findings suggest that DNA content in fibrolamellar carcinoma (FLC) is not directly related to the clinical behavior and that other factors may be responsible for the better prognosis of this variant of HCC.

KW - DNA ploidy

KW - fibrolamellar carcinoma

KW - hepatocellular carcinoma

KW - nuclear DNA content

UR - http://www.scopus.com/inward/record.url?scp=0027978728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027978728&partnerID=8YFLogxK

U2 - 10.1016/0046-8177(94)90015-9

DO - 10.1016/0046-8177(94)90015-9

M3 - Article

VL - 25

SP - 936

EP - 939

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 9

ER -