DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer

Amy Sharma, Christoph J. Heuck, Melissa J. Fazzari, Jayesh Mehta, Seema Singhal, John M. Greally, Amit K. Verma

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Epigenetics refers to heritable modifications of the genome that are not a result of changes in the DNA sequence and result in phenotypic changes. These changes can be stably transmitted through cell division and are potentially reversible. Epigenetic events are very important during normal development wherein a single progenitor cell proliferates and differentiates into various somatic cell types. This process occurs through modification of the genome without changing the genetic code. Because epigenetic control of gene expression is so important, aberrant epigenetic regulation can lead to disease and cancer. This article reviews epigenetic changes seen in cancer by examining epigenetic changes commonly found in multiple myeloma, a common hematologic malignancy of plasma cells. Epigenetic control of gene expression can be exerted by changes in DNA methylation, histone modifications, and expression of noncoding RNAs. Each of these regulatory mechanisms interacts with the others at different genomic locations and can be measured quantitatively within the cell, requiring that we consider these mechanisms not individually but as a biological system. DNA methylation was the earliest discovered epigenetic regulator and has been the focus of most investigations in cancer. We have thus focused on DNA methylation changes in the pathogenesis of multiple myeloma, which promises to become an excellent model for systems biological studies of epigenomic dysregulation in human disease.

Original languageEnglish (US)
Pages (from-to)654-669
Number of pages16
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume2
Issue number6
DOIs
StatePublished - Nov 2010

Fingerprint

DNA Methylation
Multiple Myeloma
Epigenomics
Biological systems
Gene expression
Genes
Neoplasms
Untranslated RNA
DNA sequences
Histones
Cells
Plasmas
Histone Code
Genome
Genetic Code
Gene Expression
Biological Models
Hematologic Neoplasms
Plasma Cells
Cell Division

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer. / Sharma, Amy; Heuck, Christoph J.; Fazzari, Melissa J.; Mehta, Jayesh; Singhal, Seema; Greally, John M.; Verma, Amit K.

In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 2, No. 6, 11.2010, p. 654-669.

Research output: Contribution to journalArticle

Sharma, Amy ; Heuck, Christoph J. ; Fazzari, Melissa J. ; Mehta, Jayesh ; Singhal, Seema ; Greally, John M. ; Verma, Amit K. / DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer. In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2010 ; Vol. 2, No. 6. pp. 654-669.
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