DNA damage response, redox status and hematopoiesis

Cary N. Weiss, Keisuke Ito

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The ability of hematopoietic stem cells (HSCs) to self-renew and differentiate into progenitors is essential for homeostasis of the hematopoietic system. The longevity of HSCs makes them vulnerable to accumulating DNA damage, which may be leukemogenic or result in senescence and cell death. Additionally, the ability of HSCs to self-renew and differentiate allows DNA damage to spread throughout the hematologic system, leaving the organism vulnerable to disease. In this review we discuss cell fate decisions made in the face of DNA damage and other cellular stresses, and the role of reactive oxygen species in the long-term maintenance of HSCs and their DNA damage response.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalBlood Cells, Molecules, and Diseases
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Ataxia-telangiectasia mutated
  • DNA damage
  • Hematopoietic stem cells
  • Reactive oxygen species

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Hematology
  • Cell Biology

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