TY - JOUR
T1 - DNA damage response, redox status and hematopoiesis
AU - Weiss, Cary N.
AU - Ito, Keisuke
N1 - Funding Information:
We are thankful to the Ito lab members for the comments and discussion on DNA damage responses in stem cells. K.I. is supported by grants from the NIH ( R00CA139009 , R01DK98263 ). C.W. is supported by an NIH MSTP training grant ( T32-GM007288 ). Many original articles were omitted due to space limitations; for this, we apologize.
PY - 2014/1
Y1 - 2014/1
N2 - The ability of hematopoietic stem cells (HSCs) to self-renew and differentiate into progenitors is essential for homeostasis of the hematopoietic system. The longevity of HSCs makes them vulnerable to accumulating DNA damage, which may be leukemogenic or result in senescence and cell death. Additionally, the ability of HSCs to self-renew and differentiate allows DNA damage to spread throughout the hematologic system, leaving the organism vulnerable to disease. In this review we discuss cell fate decisions made in the face of DNA damage and other cellular stresses, and the role of reactive oxygen species in the long-term maintenance of HSCs and their DNA damage response.
AB - The ability of hematopoietic stem cells (HSCs) to self-renew and differentiate into progenitors is essential for homeostasis of the hematopoietic system. The longevity of HSCs makes them vulnerable to accumulating DNA damage, which may be leukemogenic or result in senescence and cell death. Additionally, the ability of HSCs to self-renew and differentiate allows DNA damage to spread throughout the hematologic system, leaving the organism vulnerable to disease. In this review we discuss cell fate decisions made in the face of DNA damage and other cellular stresses, and the role of reactive oxygen species in the long-term maintenance of HSCs and their DNA damage response.
KW - Ataxia-telangiectasia mutated
KW - DNA damage
KW - Hematopoietic stem cells
KW - Reactive oxygen species
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U2 - 10.1016/j.bcmd.2013.08.002
DO - 10.1016/j.bcmd.2013.08.002
M3 - Article
C2 - 24041596
AN - SCOPUS:84888323327
SN - 1079-9796
VL - 52
SP - 12
EP - 18
JO - Blood Cells, Molecules, and Diseases
JF - Blood Cells, Molecules, and Diseases
IS - 1
ER -