DNA damage and ageing

New-age ideas for an age-old problem

George A. Garinis, Gijsbertus T J van der Horst, Jan Vijg, Jan H J Hoeijmakers

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.

Original languageEnglish (US)
Pages (from-to)1241-1247
Number of pages7
JournalNature Cell Biology
Volume10
Issue number11
DOIs
StatePublished - 2008

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DNA Damage
Maintenance
Genome
Pathology
Mutation
Survival
Growth
Neoplasms

ASJC Scopus subject areas

  • Cell Biology

Cite this

Garinis, G. A., van der Horst, G. T. J., Vijg, J., & Hoeijmakers, J. H. J. (2008). DNA damage and ageing: New-age ideas for an age-old problem. Nature Cell Biology, 10(11), 1241-1247. https://doi.org/10.1038/ncb1108-1241

DNA damage and ageing : New-age ideas for an age-old problem. / Garinis, George A.; van der Horst, Gijsbertus T J; Vijg, Jan; Hoeijmakers, Jan H J.

In: Nature Cell Biology, Vol. 10, No. 11, 2008, p. 1241-1247.

Research output: Contribution to journalArticle

Garinis, GA, van der Horst, GTJ, Vijg, J & Hoeijmakers, JHJ 2008, 'DNA damage and ageing: New-age ideas for an age-old problem', Nature Cell Biology, vol. 10, no. 11, pp. 1241-1247. https://doi.org/10.1038/ncb1108-1241
Garinis, George A. ; van der Horst, Gijsbertus T J ; Vijg, Jan ; Hoeijmakers, Jan H J. / DNA damage and ageing : New-age ideas for an age-old problem. In: Nature Cell Biology. 2008 ; Vol. 10, No. 11. pp. 1241-1247.
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