Divalproex treatment for youth with explosive temper and mood lability

A double-blind, placebo-controlled crossover design

Stephen J. Donovan, Jonathan W. Stewart, Edward V. Nunes, Frederic M. Quitkin, Michael K. Parides, William Daniel, Ezra Susser, Donald F. Klein

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Objective: The authors sought to replicate open-label findings showing that specific criteria for explosive temper and mood lability identify disruptive youth who improve while receiving the anticonvulsant divalproex sodium. Method: Twenty outpatient children and adolescents (ages 10-18) with a disruptive behavior disorder (oppositional defiant disorder or conduct disorder) met the specific criteria for explosive temper and mood lability. They received 6 weeks of divalproex treatment and 6 weeks of placebo by random assignment. Independent evaluators blind to group assignment assessed response at the end of each phase. Results: At the end of phase 1, eight of 10 subjects had responded to divalproex; zero of 10 had responded to placebo. Of the 15 subjects who completed both phases, 12 has superior response taking divalproex. Conclusions: This preliminary study replicates open-label findings showing that divalproex is an efficacious treatment for explosive temper and mood lability in disruptive children and adolescents.

Original languageEnglish (US)
Pages (from-to)818-820
Number of pages3
JournalAmerican Journal of Psychiatry
Volume157
Issue number5
DOIs
StatePublished - May 1 2000
Externally publishedYes

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Valproic Acid
Cross-Over Studies
Placebos
Attention Deficit and Disruptive Behavior Disorders
Therapeutics
Conduct Disorder
Anticonvulsants
Outpatients

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Divalproex treatment for youth with explosive temper and mood lability : A double-blind, placebo-controlled crossover design. / Donovan, Stephen J.; Stewart, Jonathan W.; Nunes, Edward V.; Quitkin, Frederic M.; Parides, Michael K.; Daniel, William; Susser, Ezra; Klein, Donald F.

In: American Journal of Psychiatry, Vol. 157, No. 5, 01.05.2000, p. 818-820.

Research output: Contribution to journalArticle

Donovan, Stephen J. ; Stewart, Jonathan W. ; Nunes, Edward V. ; Quitkin, Frederic M. ; Parides, Michael K. ; Daniel, William ; Susser, Ezra ; Klein, Donald F. / Divalproex treatment for youth with explosive temper and mood lability : A double-blind, placebo-controlled crossover design. In: American Journal of Psychiatry. 2000 ; Vol. 157, No. 5. pp. 818-820.
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