Disulfiram Treatment Normalizes Body Weight in Obese Mice

Michel Bernier, Sarah J. Mitchell, Devin Wahl, Antonio Diaz, Abhishek Singh, Wonhyo Seo, Mingy Wang, Ahmed Ali, Tamzin Kaiser, Nathan L. Price, Miguel A. Aon, Eun Young Kim, Michael A. Petr, Huan Cai, Alessa Warren, Clara Di Germanio, Andrea Di Francesco, Ken Fishbein, Vince Guiterrez, Dylan HarneyYen Chin Koay, John Mach, Ignacio Navas Enamorado, Tamara Pulpitel, Yushi Wang, Jing Zhang, Li Zhang, Richard G. Spencer, Kevin G. Becker, Josephine M. Egan, Edward G. Lakatta, John O'Sullivan, Mark Larance, David G. LeCouteur, Victoria C. Cogger, Bin Gao, Carlos Fernandez-Hernando, Ana Maria Cuervo, Rafael de Cabo

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In this study, Bernier et al. report on the off-label use of disulfiram to combat diet-induced obesity in mice through normalization of body weight and improvement of various physiological outcomes related to body composition and insulin responsiveness.

Original languageEnglish (US)
Pages (from-to)203-214.e4
JournalCell metabolism
Volume32
Issue number2
DOIs
StatePublished - Aug 4 2020

Keywords

  • beta-cell hyperplasia
  • fibrosis
  • hepatic steatosis
  • inflammation
  • insulin resistance
  • obesity
  • weight gain

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Bernier, M., Mitchell, S. J., Wahl, D., Diaz, A., Singh, A., Seo, W., Wang, M., Ali, A., Kaiser, T., Price, N. L., Aon, M. A., Kim, E. Y., Petr, M. A., Cai, H., Warren, A., Di Germanio, C., Di Francesco, A., Fishbein, K., Guiterrez, V., ... de Cabo, R. (2020). Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell metabolism, 32(2), 203-214.e4. https://doi.org/10.1016/j.cmet.2020.04.019