Disulfide bonds are required for Serratia marcescens nuclease activity

Timothy K. Ball, Yousin Suh, Michael J. Benedik

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The role of the two disulfide bonds found in the Serratia marcescens nuclease were tested by site directed mutagenesis and were found essential for nuclease activity, although slight residual activity remained. The requirement for disulfide bond formation may play a role in preventing the lethal action of nuclease while in the bacterial cytoplasm.

Original languageEnglish (US)
Pages (from-to)4971-4974
Number of pages4
JournalNucleic acids research
Issue number19
StatePublished - Oct 11 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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