Distribution of epithelial membrane antigen in normal and neoplastic human ependyma

Y. Uematsu, R. R. Rojas-Corona, J. F. Llena, A. Hirano

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The ependyma and choroid plexus of 23 normal brains and 20 ependymal tumors were examined immunohistochemically for expression of epithelial membrane antigen (EMA) using a specific monoclonal antibody. The ependyma of normal brains showed three patterns of immunoreactivity: membrane immunoreactivity confined to the luminal surface; irregular punctate intracytoplasmic immunore-activity in the subependymal layer; and spherical and ring-like intracytoplasmic immunoreactivity in the subependymal layer. Of 13 differentiated ependymomas 11 reflected the immunoreactive patterns of normal ependyma. The anaplastic ependymomas and ependymoblastomas had no immunoreactivity. Our results indicate that EMA has a highly selective distribution in the ependyma, and is a marker for differentiated ependymoma.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalActa Neuropathologica
Volume78
Issue number3
DOIs
StatePublished - May 1989

Fingerprint

Ependyma
Mucin-1
Ependymoma
Primitive Neuroectodermal Tumors
Choroid Plexus
Brain
Monoclonal Antibodies
Membranes
Neoplasms

Keywords

  • Ependyma
  • Ependymoma
  • Epithelial membrane antigen
  • Immunohistochemistry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Distribution of epithelial membrane antigen in normal and neoplastic human ependyma. / Uematsu, Y.; Rojas-Corona, R. R.; Llena, J. F.; Hirano, A.

In: Acta Neuropathologica, Vol. 78, No. 3, 05.1989, p. 325-328.

Research output: Contribution to journalArticle

Uematsu, Y, Rojas-Corona, RR, Llena, JF & Hirano, A 1989, 'Distribution of epithelial membrane antigen in normal and neoplastic human ependyma', Acta Neuropathologica, vol. 78, no. 3, pp. 325-328. https://doi.org/10.1007/BF00687763
Uematsu, Y. ; Rojas-Corona, R. R. ; Llena, J. F. ; Hirano, A. / Distribution of epithelial membrane antigen in normal and neoplastic human ependyma. In: Acta Neuropathologica. 1989 ; Vol. 78, No. 3. pp. 325-328.
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