Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin

Robert Maxson, Timothy Mohun, Glen Gormezano, Geoffrey J. Childs, Larry Kedes

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The set of histone genes that are active late in embryogenesis of the sea urchin (Strongylocentrotus purpuratus) are present in 5-12 copies per genome and, unlike the clustered, tandemly arrayed early histone genes, are dispersed and irregularly arranged. Late H2B gene expression is activated by events accompanying fertilization and its mRNAs are first detectable by as early as 6 h of development (16 cells) and increase only slightly in amount during the period of rapid cleavage between 6 and 14 h. However, during the short interval between 14 and 16 h, while the amount of early histone mRNA is declining, there is a >15-fold burst in the rate of late H2B mRNA accumulation.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalNature
Volume301
Issue number5896
DOIs
StatePublished - 1983

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Sea Urchins
Histones
Messenger RNA
Strongylocentrotus purpuratus
Genes
Fertilization
Embryonic Development
Genome
Gene Expression

ASJC Scopus subject areas

  • General

Cite this

Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin. / Maxson, Robert; Mohun, Timothy; Gormezano, Glen; Childs, Geoffrey J.; Kedes, Larry.

In: Nature, Vol. 301, No. 5896, 1983, p. 120-125.

Research output: Contribution to journalArticle

Maxson, Robert ; Mohun, Timothy ; Gormezano, Glen ; Childs, Geoffrey J. ; Kedes, Larry. / Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin. In: Nature. 1983 ; Vol. 301, No. 5896. pp. 120-125.
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