Abstract
The set of histone genes that are active late in embryogenesis of the sea urchin (Strongylocentrotus purpuratus) are present in 5-12 copies per genome and, unlike the clustered, tandemly arrayed early histone genes, are dispersed and irregularly arranged. Late H2B gene expression is activated by events accompanying fertilization and its mRNAs are first detectable by as early as 6 h of development (16 cells) and increase only slightly in amount during the period of rapid cleavage between 6 and 14 h. However, during the short interval between 14 and 16 h, while the amount of early histone mRNA is declining, there is a >15-fold burst in the rate of late H2B mRNA accumulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 120-125 |
| Number of pages | 6 |
| Journal | Nature |
| Volume | 301 |
| Issue number | 5896 |
| DOIs | |
| State | Published - 1983 |
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Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin. / Maxson, Robert; Mohun, Timothy; Gormezano, Glen; Childs, Geoffrey J.; Kedes, Larry.
In: Nature, Vol. 301, No. 5896, 1983, p. 120-125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin
AU - Maxson, Robert
AU - Mohun, Timothy
AU - Gormezano, Glen
AU - Childs, Geoffrey J.
AU - Kedes, Larry
PY - 1983
Y1 - 1983
N2 - The set of histone genes that are active late in embryogenesis of the sea urchin (Strongylocentrotus purpuratus) are present in 5-12 copies per genome and, unlike the clustered, tandemly arrayed early histone genes, are dispersed and irregularly arranged. Late H2B gene expression is activated by events accompanying fertilization and its mRNAs are first detectable by as early as 6 h of development (16 cells) and increase only slightly in amount during the period of rapid cleavage between 6 and 14 h. However, during the short interval between 14 and 16 h, while the amount of early histone mRNA is declining, there is a >15-fold burst in the rate of late H2B mRNA accumulation.
AB - The set of histone genes that are active late in embryogenesis of the sea urchin (Strongylocentrotus purpuratus) are present in 5-12 copies per genome and, unlike the clustered, tandemly arrayed early histone genes, are dispersed and irregularly arranged. Late H2B gene expression is activated by events accompanying fertilization and its mRNAs are first detectable by as early as 6 h of development (16 cells) and increase only slightly in amount during the period of rapid cleavage between 6 and 14 h. However, during the short interval between 14 and 16 h, while the amount of early histone mRNA is declining, there is a >15-fold burst in the rate of late H2B mRNA accumulation.
UR - http://www.scopus.com/inward/record.url?scp=0020700665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020700665&partnerID=8YFLogxK
U2 - 10.1038/301120a0
DO - 10.1038/301120a0
M3 - Article
C2 - 6296688
AN - SCOPUS:0020700665
VL - 301
SP - 120
EP - 125
JO - Nature
JF - Nature
SN - 0028-0836
IS - 5896
ER -