Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

Christoph Straub, David L. Hunt, Miwako Yamasaki, Kwang S. Kim, Masahiko Watanabe, Pablo E. Castillo, Susumu Tomita

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors, kainate receptors (KARs) have a unique brain distribution, which has been historically defined by 3 H-radiolabeled kainate binding. Compared with recombinant KARs expressed in heterologous cells, synaptic KARs exhibit characteristically slow rise-time and decay kinetics. However, the mechanisms responsible for these distinct KAR properties remain unclear. We found that both the high-affinity binding pattern in the mouse brain and the channel properties of native KARs are determined by the KAR auxiliary subunit Neto1. Through modulation of agonist binding affinity and off-kinetics of KARs, but not trafficking of KARs, Neto1 determined both the KAR high-affinity binding pattern and the distinctively slow kinetics of postsynaptic KARs. By regulating KAR excitatory postsynaptic current kinetics, Neto1 can control synaptic temporal summation, spike generation and fidelity.

Original languageEnglish (US)
Pages (from-to)866-873
Number of pages8
JournalNature Neuroscience
Volume14
Issue number7
DOIs
StatePublished - Jul 2011

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Kainic Acid Receptors
Brain
Ionotropic Glutamate Receptors
Neurotransmitter Receptor
Excitatory Postsynaptic Potentials
Kainic Acid

ASJC Scopus subject areas

  • Neuroscience(all)

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Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. / Straub, Christoph; Hunt, David L.; Yamasaki, Miwako; Kim, Kwang S.; Watanabe, Masahiko; Castillo, Pablo E.; Tomita, Susumu.

In: Nature Neuroscience, Vol. 14, No. 7, 07.2011, p. 866-873.

Research output: Contribution to journalArticle

Straub, C, Hunt, DL, Yamasaki, M, Kim, KS, Watanabe, M, Castillo, PE & Tomita, S 2011, 'Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1', Nature Neuroscience, vol. 14, no. 7, pp. 866-873. https://doi.org/10.1038/nn.2837
Straub, Christoph ; Hunt, David L. ; Yamasaki, Miwako ; Kim, Kwang S. ; Watanabe, Masahiko ; Castillo, Pablo E. ; Tomita, Susumu. / Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. In: Nature Neuroscience. 2011 ; Vol. 14, No. 7. pp. 866-873.
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