Distinct fNIRS-Derived HbO2 Trajectories during the Course and over Repeated Walking Trials under Single-and Dual-Task Conditions: Implications for Within Session Learning and Prefrontal Cortex Efficiency in Older Adults

Roee Holtzer, Meltem Izzetoglu, Michelle Chen, Cuiling Wang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional near-infrared spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under Single-Task-Walk (STW), and Dual-Task-Walk (DTW) conditions. Course trajectory assessed neural activity associated with attention during the course of a walking task; the second trajectory assessed neural activity associated with learning over repeated walking trials. Improved neural efficiency was defined as reduced PFC HbO 2 after practice. Methods: Walking was assessed under STW and DTW conditions. fNIRS was utilized to quantify HbO2 in the PFC while walking. Burst measurement included three repeated trials for each experimental condition. The course of each walking task consisted of six consecutive segments. Results: Eighty-three nondemented participants (mean age = 78.05 ± 6.37 years; %female = 49.5) were included. Stride velocity (estimate =-0.5259 cm/s, p = <.0001) and the rate of correct letter generation (log estimate of rate ratio =-0.0377, p <.0001) declined during the course of DTW. In contrast, stride velocity (estimate = 1.4577 cm/s, p <.0001) and the rate of correct letter generation (log estimate of rate ratio = 0.0578, p <.0001) improved over repeated DTW trials. Course and trial effects were not significant in STW. HbO2 increased during the course of DTW (estimate = 0.0454 μM, p <.0001) but declined over repeated trials (estimate =-0.1786 μM, p <.0001). HbO2 declined during the course of STW (estimate =-.0542 μM, p <.0001) but did not change significantly over repeated trials. Conclusion: We provided evidence for distinct attention (course) and learning (repeated trials) trajectories and their corresponding PFC activity. Findings suggest that learning and improved PFC efficiency were demonstrated in one experimental session involving repeated DTW trials.

Original languageEnglish (US)
Pages (from-to)1076-1083
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume74
Issue number7
DOIs
StatePublished - Jun 18 2019

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Near-Infrared Spectroscopy
Prefrontal Cortex
Walking
Learning
Efficiency
Gait

Keywords

  • Brain
  • Burst measurement
  • fNIRS
  • Mobility

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

@article{28cab42881b5474aaecf037b96a66c3c,
title = "Distinct fNIRS-Derived HbO2 Trajectories during the Course and over Repeated Walking Trials under Single-and Dual-Task Conditions: Implications for Within Session Learning and Prefrontal Cortex Efficiency in Older Adults",
abstract = "Background: Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional near-infrared spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under Single-Task-Walk (STW), and Dual-Task-Walk (DTW) conditions. Course trajectory assessed neural activity associated with attention during the course of a walking task; the second trajectory assessed neural activity associated with learning over repeated walking trials. Improved neural efficiency was defined as reduced PFC HbO 2 after practice. Methods: Walking was assessed under STW and DTW conditions. fNIRS was utilized to quantify HbO2 in the PFC while walking. Burst measurement included three repeated trials for each experimental condition. The course of each walking task consisted of six consecutive segments. Results: Eighty-three nondemented participants (mean age = 78.05 ± 6.37 years; {\%}female = 49.5) were included. Stride velocity (estimate =-0.5259 cm/s, p = <.0001) and the rate of correct letter generation (log estimate of rate ratio =-0.0377, p <.0001) declined during the course of DTW. In contrast, stride velocity (estimate = 1.4577 cm/s, p <.0001) and the rate of correct letter generation (log estimate of rate ratio = 0.0578, p <.0001) improved over repeated DTW trials. Course and trial effects were not significant in STW. HbO2 increased during the course of DTW (estimate = 0.0454 μM, p <.0001) but declined over repeated trials (estimate =-0.1786 μM, p <.0001). HbO2 declined during the course of STW (estimate =-.0542 μM, p <.0001) but did not change significantly over repeated trials. Conclusion: We provided evidence for distinct attention (course) and learning (repeated trials) trajectories and their corresponding PFC activity. Findings suggest that learning and improved PFC efficiency were demonstrated in one experimental session involving repeated DTW trials.",
keywords = "Brain, Burst measurement, fNIRS, Mobility",
author = "Roee Holtzer and Meltem Izzetoglu and Michelle Chen and Cuiling Wang",
year = "2019",
month = "6",
day = "18",
doi = "10.1093/gerona/gly181",
language = "English (US)",
volume = "74",
pages = "1076--1083",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
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number = "7",

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TY - JOUR

T1 - Distinct fNIRS-Derived HbO2 Trajectories during the Course and over Repeated Walking Trials under Single-and Dual-Task Conditions

T2 - Implications for Within Session Learning and Prefrontal Cortex Efficiency in Older Adults

AU - Holtzer, Roee

AU - Izzetoglu, Meltem

AU - Chen, Michelle

AU - Wang, Cuiling

PY - 2019/6/18

Y1 - 2019/6/18

N2 - Background: Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional near-infrared spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under Single-Task-Walk (STW), and Dual-Task-Walk (DTW) conditions. Course trajectory assessed neural activity associated with attention during the course of a walking task; the second trajectory assessed neural activity associated with learning over repeated walking trials. Improved neural efficiency was defined as reduced PFC HbO 2 after practice. Methods: Walking was assessed under STW and DTW conditions. fNIRS was utilized to quantify HbO2 in the PFC while walking. Burst measurement included three repeated trials for each experimental condition. The course of each walking task consisted of six consecutive segments. Results: Eighty-three nondemented participants (mean age = 78.05 ± 6.37 years; %female = 49.5) were included. Stride velocity (estimate =-0.5259 cm/s, p = <.0001) and the rate of correct letter generation (log estimate of rate ratio =-0.0377, p <.0001) declined during the course of DTW. In contrast, stride velocity (estimate = 1.4577 cm/s, p <.0001) and the rate of correct letter generation (log estimate of rate ratio = 0.0578, p <.0001) improved over repeated DTW trials. Course and trial effects were not significant in STW. HbO2 increased during the course of DTW (estimate = 0.0454 μM, p <.0001) but declined over repeated trials (estimate =-0.1786 μM, p <.0001). HbO2 declined during the course of STW (estimate =-.0542 μM, p <.0001) but did not change significantly over repeated trials. Conclusion: We provided evidence for distinct attention (course) and learning (repeated trials) trajectories and their corresponding PFC activity. Findings suggest that learning and improved PFC efficiency were demonstrated in one experimental session involving repeated DTW trials.

AB - Background: Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional near-infrared spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under Single-Task-Walk (STW), and Dual-Task-Walk (DTW) conditions. Course trajectory assessed neural activity associated with attention during the course of a walking task; the second trajectory assessed neural activity associated with learning over repeated walking trials. Improved neural efficiency was defined as reduced PFC HbO 2 after practice. Methods: Walking was assessed under STW and DTW conditions. fNIRS was utilized to quantify HbO2 in the PFC while walking. Burst measurement included three repeated trials for each experimental condition. The course of each walking task consisted of six consecutive segments. Results: Eighty-three nondemented participants (mean age = 78.05 ± 6.37 years; %female = 49.5) were included. Stride velocity (estimate =-0.5259 cm/s, p = <.0001) and the rate of correct letter generation (log estimate of rate ratio =-0.0377, p <.0001) declined during the course of DTW. In contrast, stride velocity (estimate = 1.4577 cm/s, p <.0001) and the rate of correct letter generation (log estimate of rate ratio = 0.0578, p <.0001) improved over repeated DTW trials. Course and trial effects were not significant in STW. HbO2 increased during the course of DTW (estimate = 0.0454 μM, p <.0001) but declined over repeated trials (estimate =-0.1786 μM, p <.0001). HbO2 declined during the course of STW (estimate =-.0542 μM, p <.0001) but did not change significantly over repeated trials. Conclusion: We provided evidence for distinct attention (course) and learning (repeated trials) trajectories and their corresponding PFC activity. Findings suggest that learning and improved PFC efficiency were demonstrated in one experimental session involving repeated DTW trials.

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KW - Burst measurement

KW - fNIRS

KW - Mobility

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DO - 10.1093/gerona/gly181

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