TY - JOUR
T1 - Distinct fNIRS-Derived HbO2 Trajectories during the Course and over Repeated Walking Trials under Single-and Dual-Task Conditions
T2 - Implications for Within Session Learning and Prefrontal Cortex Efficiency in Older Adults
AU - Holtzer, Roee
AU - Izzetoglu, Meltem
AU - Chen, Michelle
AU - Wang, Cuiling
N1 - Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2019/6/18
Y1 - 2019/6/18
N2 - Background: Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional near-infrared spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under Single-Task-Walk (STW), and Dual-Task-Walk (DTW) conditions. Course trajectory assessed neural activity associated with attention during the course of a walking task; the second trajectory assessed neural activity associated with learning over repeated walking trials. Improved neural efficiency was defined as reduced PFC HbO 2 after practice. Methods: Walking was assessed under STW and DTW conditions. fNIRS was utilized to quantify HbO2 in the PFC while walking. Burst measurement included three repeated trials for each experimental condition. The course of each walking task consisted of six consecutive segments. Results: Eighty-three nondemented participants (mean age = 78.05 ± 6.37 years; %female = 49.5) were included. Stride velocity (estimate =-0.5259 cm/s, p = <.0001) and the rate of correct letter generation (log estimate of rate ratio =-0.0377, p <.0001) declined during the course of DTW. In contrast, stride velocity (estimate = 1.4577 cm/s, p <.0001) and the rate of correct letter generation (log estimate of rate ratio = 0.0578, p <.0001) improved over repeated DTW trials. Course and trial effects were not significant in STW. HbO2 increased during the course of DTW (estimate = 0.0454 μM, p <.0001) but declined over repeated trials (estimate =-0.1786 μM, p <.0001). HbO2 declined during the course of STW (estimate =-.0542 μM, p <.0001) but did not change significantly over repeated trials. Conclusion: We provided evidence for distinct attention (course) and learning (repeated trials) trajectories and their corresponding PFC activity. Findings suggest that learning and improved PFC efficiency were demonstrated in one experimental session involving repeated DTW trials.
AB - Background: Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional near-infrared spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under Single-Task-Walk (STW), and Dual-Task-Walk (DTW) conditions. Course trajectory assessed neural activity associated with attention during the course of a walking task; the second trajectory assessed neural activity associated with learning over repeated walking trials. Improved neural efficiency was defined as reduced PFC HbO 2 after practice. Methods: Walking was assessed under STW and DTW conditions. fNIRS was utilized to quantify HbO2 in the PFC while walking. Burst measurement included three repeated trials for each experimental condition. The course of each walking task consisted of six consecutive segments. Results: Eighty-three nondemented participants (mean age = 78.05 ± 6.37 years; %female = 49.5) were included. Stride velocity (estimate =-0.5259 cm/s, p = <.0001) and the rate of correct letter generation (log estimate of rate ratio =-0.0377, p <.0001) declined during the course of DTW. In contrast, stride velocity (estimate = 1.4577 cm/s, p <.0001) and the rate of correct letter generation (log estimate of rate ratio = 0.0578, p <.0001) improved over repeated DTW trials. Course and trial effects were not significant in STW. HbO2 increased during the course of DTW (estimate = 0.0454 μM, p <.0001) but declined over repeated trials (estimate =-0.1786 μM, p <.0001). HbO2 declined during the course of STW (estimate =-.0542 μM, p <.0001) but did not change significantly over repeated trials. Conclusion: We provided evidence for distinct attention (course) and learning (repeated trials) trajectories and their corresponding PFC activity. Findings suggest that learning and improved PFC efficiency were demonstrated in one experimental session involving repeated DTW trials.
KW - Brain
KW - Burst measurement
KW - Mobility
KW - fNIRS
UR - http://www.scopus.com/inward/record.url?scp=85061310716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061310716&partnerID=8YFLogxK
U2 - 10.1093/gerona/gly181
DO - 10.1093/gerona/gly181
M3 - Article
C2 - 30107534
AN - SCOPUS:85061310716
SN - 1079-5006
VL - 74
SP - 1076
EP - 1083
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 7
ER -