Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies

Greg H. Bird, Evripidis Gavathiotis, James L. Labelle, Samuel G. Katz, Loren D. Walensky

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Hydrocarbon stapling is a chemical approach to restoring and fortifying the natural α-helical structure of peptides that otherwise unfold when taken out of context from the host protein. By iterating the peptide sequence, staple type, and sites of insertion, discrete compositions can be generated to suit a diversity of biochemical, structural, proteomic, cellular, and drug development applications. Here, we reinforce key design considerations to avoid pitfalls and maximize progress when applying stapled peptides in chemistry and biology research.

Original languageEnglish (US)
Pages (from-to)831-837
Number of pages7
JournalACS Chemical Biology
Volume9
Issue number3
DOIs
StatePublished - Mar 21 2014

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Peptides
Hydrocarbons
Proteomics
Chemical analysis
Research
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Medicine(all)

Cite this

Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. / Bird, Greg H.; Gavathiotis, Evripidis; Labelle, James L.; Katz, Samuel G.; Walensky, Loren D.

In: ACS Chemical Biology, Vol. 9, No. 3, 21.03.2014, p. 831-837.

Research output: Contribution to journalArticle

Bird, Greg H. ; Gavathiotis, Evripidis ; Labelle, James L. ; Katz, Samuel G. ; Walensky, Loren D. / Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. In: ACS Chemical Biology. 2014 ; Vol. 9, No. 3. pp. 831-837.
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