Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia

Elisabeth M. Paietta, M. Andreeff, P. Papenhausen, Rasim A. Gucalp, P. H. Wiernik

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Three cell populations with different DNA indices were demonstrated in a case of biphenotypic terminal transferase (TdT)/myeloid-positive acute leukemia which had developed from a pre-leukemic diploid population also expressing biphenotypic features. At the time of development of acute leukemia, flow-cytometric analysis revealed expression of TdT by the diploid, the tetraploid, and the near-triploid cells, but only the tetraploid cells carried the myeloid-specific M2 antigen. Cytogenetic analysis showed four stemlines, diploid, tetraploid, tetraploid with del(2), and near-triploid with del(2) and variable chromosome losses. In vitro treatment with retinoic acid induced the expression of the M2 antigen by the diploid cells as well. This in vitro result is consistent with a myeloid differentiation commitment of the pluripotent leukemic stem cell.

Original languageEnglish (US)
Pages (from-to)76-78
Number of pages3
JournalLeukemia
Volume3
Issue number1
StatePublished - 1989

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Tetraploidy
Ploidies
Diploidy
Leukemia
Antigens
Triploidy
DNA
Pluripotent Stem Cells
Chromosomes, Human, Pair 2
Cytogenetic Analysis
Myeloid Cells
Transferases
Tretinoin
Acute Myeloid Leukemia
Population
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia. / Paietta, Elisabeth M.; Andreeff, M.; Papenhausen, P.; Gucalp, Rasim A.; Wiernik, P. H.

In: Leukemia, Vol. 3, No. 1, 1989, p. 76-78.

Research output: Contribution to journalArticle

Paietta, EM, Andreeff, M, Papenhausen, P, Gucalp, RA & Wiernik, PH 1989, 'Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia', Leukemia, vol. 3, no. 1, pp. 76-78.
Paietta, Elisabeth M. ; Andreeff, M. ; Papenhausen, P. ; Gucalp, Rasim A. ; Wiernik, P. H. / Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia. In: Leukemia. 1989 ; Vol. 3, No. 1. pp. 76-78.
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