Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis

Remco De Bree; Missak Haigentz; Carl E. Silver; Daniela Paccagnella; Marc Hamoir; Dana M. Hartl; Jean Pascal MacHiels; Vinidh Paleri; Alessandra Rinaldo; Ashok R. Shaha; Robert P. Takes; C. René Leemans; Alfio Ferlito

doi:10.1016/j.oraloncology.2012.03.014

Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis

Remco De Bree, Missak Haigentz, Carl E. Silver, Daniela Paccagnella, Marc Hamoir, Dana M. Hartl, Jean Pascal MacHiels, Vinidh Paleri, Alessandra Rinaldo, Ashok R. Shaha, Robert P. Takes, C. René Leemans, Alfio Ferlito

Medicine

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.

Original language	English (US)
Pages (from-to)	780-786
Number of pages	7
Journal	Oral Oncology
Volume	48
Issue number	9
DOIs	https://doi.org/10.1016/j.oraloncology.2012.03.014
State	Published - Sep 2012

Keywords

CT
Diagnostic techniques
Distant metastases
FDG-PET
Head and neck squamous cell carcinoma
Risk factors

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2012.03.014

Cite this

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title = "Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis",

abstract = "The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.",

keywords = "CT, Diagnostic techniques, Distant metastases, FDG-PET, Head and neck squamous cell carcinoma, Risk factors",

author = "{De Bree}, Remco and Missak Haigentz and Silver, {Carl E.} and Daniela Paccagnella and Marc Hamoir and Hartl, {Dana M.} and MacHiels, {Jean Pascal} and Vinidh Paleri and Alessandra Rinaldo and Shaha, {Ashok R.} and Takes, {Robert P.} and Leemans, {C. Ren{\'e}} and Alfio Ferlito",

year = "2012",

month = sep,

doi = "10.1016/j.oraloncology.2012.03.014",

language = "English (US)",

volume = "48",

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AU - De Bree, Remco

AU - Haigentz, Missak

AU - Silver, Carl E.

AU - Paccagnella, Daniela

AU - Hamoir, Marc

AU - Hartl, Dana M.

AU - MacHiels, Jean Pascal

AU - Paleri, Vinidh

AU - Rinaldo, Alessandra

AU - Shaha, Ashok R.

AU - Takes, Robert P.

AU - Leemans, C. René

AU - Ferlito, Alfio

PY - 2012/9

Y1 - 2012/9

N2 - The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.

AB - The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.

KW - CT

KW - Diagnostic techniques

KW - Distant metastases

KW - FDG-PET

KW - Head and neck squamous cell carcinoma

KW - Risk factors

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Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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