Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward

Ken T. Wakabayashi, Howard L. Fields, Saleem M. Nicola

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The choice among behavioral options is influenced by the anticipated cost of working for the reward relative to the anticipated reward magnitude. Dopamine release in the nucleus accumbens (NAc) has been suggested to play an important role in cost/benefit computation. From a behavioral perspective, work involves two elements: the caloric expenditure of energy and the time required to complete the task. In many studies of the contribution of NAc dopamine to cost/benefit decisions, measures of work have conflated these separate elements. Here we describe a novel cued progressive delay task, an analog of the progressive ratio task that minimizes energy expenditure. In this task, rats obtain sucrose reward by entering a reward receptacle in response to a cue and remaining in the receptacle for a required wait that is increased after each successful trial. In an experiment in which the magnitude of reward was varied across sessions, the animals' fail point (maximum wait achieved) was correlated with the amount of reward delivered. Microinjection of D1 or D2 dopamine receptor antagonists into the NAc did not affect the length of time animals were willing to wait for reward (fail point), but did reduce the proportion of cues to which the animal responded. These results suggest that waiting for reward without increased caloric energy expenditure does not require NAc dopamine.

Original languageEnglish (US)
Pages (from-to)19-30
Number of pages12
JournalBehavioural Brain Research
Volume154
Issue number1
DOIs
StatePublished - Sep 23 2004
Externally publishedYes

Fingerprint

Nucleus Accumbens
Reward
Cues
Dopamine
Energy Metabolism
Cost-Benefit Analysis
Microinjections
Sucrose
Costs and Cost Analysis

Keywords

  • Accumbens
  • Delay discounting
  • Dopamine
  • Impulsive choice
  • Incentive motivation
  • Progressive ratio
  • Reward
  • Ventral striatum

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward. / Wakabayashi, Ken T.; Fields, Howard L.; Nicola, Saleem M.

In: Behavioural Brain Research, Vol. 154, No. 1, 23.09.2004, p. 19-30.

Research output: Contribution to journalArticle

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