Dissociation of serum triiodothyronine concentration and hepatic nuclear triiodothyronine-binding capacity in streptozotocin-induced diabetic rats

To determine the relationship between the concentrations of serum T₃and hepatic nuclear T₃receptor in a reversible nonthyroidal disease, we studied these parameters in rats with streptozotocin-induced diabetes mellitus, control rats, and rats that were weight-matched to the diabetic rats by food restriction. Results were similar either 1 or 9 weeks after the induction of diabetes. A significant decrease from control in mean serum T₄ T₃and free T₃index was noted in the diabetic rats. However, mean serum TSH was not altered significantly. The hepatic nuclear T₃-binding capacity in the diabetic rats was similar to that in the control at both time intervals, whereas the nuclear T₃-binding capacity of fasted rats was decreased. The dissociation of serum T3 and hepatic nuclear receptor concentrations in diabetic rats suggests that receptor concentration is not modified by thyroid hormones in this nonthyroidal disease.