Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum

Laeben Lester, Naoto Uemura, John Ademola, Martha R. Harkey, Rajneesh P. Nath, Seong J. Kim, Elina Jerschow, Gary L. Henderson, John Mendelson, Reese T. Jones

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to determine whether or not the skin acts as a reservoir for cocaine. Cocaine-d5 (1 mg/kg) was administered to five nondependent, cocaine-experienced volunteers. Skin tissue, interstitial fluid, sebum, stratum corneum, and plasma were collected for 72 h after drug administration. Cocaine and benzoylecgonine (BE) levels were determined using GC-MS. Cocaine concentrations peaked in plasma at 1 h after administration, with pharmacokinetic parameters (t1/2, CL, Vd) also in the expected ranges. In skin, cocaine levels peaked around 1.5 h after administration and became undetectable by 6 h. A correlation was found between the plasma and skin AUC for cocaine (R = 0.99, p = 0.006, N = 4). BE was not detected in skin. In interstitial fluid (N = 4), cocaine concentrations peaked around 5 h after drug administration and were undetectable by 24 h. BE peaks varied between 2 and 24 h and were not detectable at 48 h. In sebum, cocaine levels peaked between 3 and 24 h. BE was found in three samples between 12 and 24 h. In stratum corneum, cocaine was measurable in only one sample from one subject. These findings suggest that skin does not act as a reservoir for cocaine. Rather, cocaine appears to be distributed rapidly to the skin and eliminated, following a time course similar to that of plasma.

Original languageEnglish (US)
Pages (from-to)547-553
Number of pages7
JournalJournal of Analytical Toxicology
Volume26
Issue number8
StatePublished - Nov 2002
Externally publishedYes

Fingerprint

Sebum
Extracellular Fluid
Cocaine
Cornea
skin
Skin
Fluids
fluid
Plasmas
plasma
drug
Pharmacokinetics
Tissue
Pharmaceutical Preparations
Area Under Curve
Volunteers

ASJC Scopus subject areas

  • Analytical Chemistry
  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Lester, L., Uemura, N., Ademola, J., Harkey, M. R., Nath, R. P., Kim, S. J., ... Jones, R. T. (2002). Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum. Journal of Analytical Toxicology, 26(8), 547-553.

Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum. / Lester, Laeben; Uemura, Naoto; Ademola, John; Harkey, Martha R.; Nath, Rajneesh P.; Kim, Seong J.; Jerschow, Elina; Henderson, Gary L.; Mendelson, John; Jones, Reese T.

In: Journal of Analytical Toxicology, Vol. 26, No. 8, 11.2002, p. 547-553.

Research output: Contribution to journalArticle

Lester, L, Uemura, N, Ademola, J, Harkey, MR, Nath, RP, Kim, SJ, Jerschow, E, Henderson, GL, Mendelson, J & Jones, RT 2002, 'Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum', Journal of Analytical Toxicology, vol. 26, no. 8, pp. 547-553.
Lester L, Uemura N, Ademola J, Harkey MR, Nath RP, Kim SJ et al. Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum. Journal of Analytical Toxicology. 2002 Nov;26(8):547-553.
Lester, Laeben ; Uemura, Naoto ; Ademola, John ; Harkey, Martha R. ; Nath, Rajneesh P. ; Kim, Seong J. ; Jerschow, Elina ; Henderson, Gary L. ; Mendelson, John ; Jones, Reese T. / Disposition of cocaine in skin, interstitial fluid, sebum, and stratum corneum. In: Journal of Analytical Toxicology. 2002 ; Vol. 26, No. 8. pp. 547-553.
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