Disordered food intake and obesity in rats lacking cholecystokinin A receptors

Timothy H. Moran, Laura F. Katz, Carlos R. Plata-Salaman, Gary J. Schwartz

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

Otsuka Long-Evans Tokushima Fatty (OLETF) rats develop obesity, hyperglycemia, and non-insulin-dependent diabetes mellitus and do not express cholecystokinin A (CCK-A) receptors, the receptor subtype mediating the satiety actions of CCK. In short-term feeding tests, male OLETF rats were completely resistant to exogenous CCK, and their response to bombesin was attenuated. Comparisons of liquid meal consumption in OLETF and control Long- Evans Tokushima (LETO) rats demonstrated that 1) OLETF rats had greater intakes during 30-min scheduled daytime meals and significantly larger and fewer spontaneous night-time meals and 2) although the initial rates of licking were the same, OLETF rats maintained the initial rate longer and the rate at which their licking declined was slower. In 24-h solid food access tests, OLETF rats consumed significantly more pellets than LETO controls, and this increase was attributable to significant increases in meal size. Together, these data are consistent with the interpretation that the lack of CCK-A receptors in OLETF rats results in a satiety deficit leading to increases in meal size, overall hyperphagia, and obesity.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume274
Issue number3 43-3
StatePublished - Mar 1998
Externally publishedYes

Fingerprint

Inbred OLETF Rats
Cholecystokinin A Receptor
Obesity
Eating
Meals
Bombesin
Hyperphagia
Long Evans Rats
Hyperglycemia
Type 2 Diabetes Mellitus
Food

Keywords

  • Bombesin
  • Hyperphagia
  • Peptides
  • Satiety

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Disordered food intake and obesity in rats lacking cholecystokinin A receptors. / Moran, Timothy H.; Katz, Laura F.; Plata-Salaman, Carlos R.; Schwartz, Gary J.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 274, No. 3 43-3, 03.1998.

Research output: Contribution to journalArticle

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