Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

Yuli Xie; Yidong Liu; Gangli Gong; Deborah H. Smith; Fang Yan; Alison Rinderspacher; Yan Feng; Zhengxiang Zhu; Xiangpo Li; Shi Xian Deng; Lars Branden; Dušica Vidović; Caty Chung; Stephan Schürer; Christophe Morisseau; Bruce D. Hammock; Donald W. Landry

doi:10.1016/j.bmcl.2008.09.066

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

Yuli Xie, Yidong Liu, Gangli Gong, Deborah H. Smith, Fang Yan, Alison Rinderspacher, Yan Feng, Zhengxiang Zhu, Xiangpo Li, Shi Xian Deng, Lars Branden, Dušica Vidović, Caty Chung, Stephan Schürer, Christophe Morisseau, Bruce D. Hammock, Donald W. Landry

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC₅₀s of the most potent compounds range from micromolar to low nanomolar.

Original language	English (US)
Pages (from-to)	2354-2359
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2008.09.066
State	Published - Apr 15 2009
Externally published	Yes

Keywords

HTS
Nanomolar
Non-urea
sEH

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2008.09.066

Cite this

Xie, Y., Liu, Y., Gong, G., Smith, D. H., Yan, F., Rinderspacher, A., Feng, Y., Zhu, Z., Li, X., Deng, S. X., Branden, L., Vidović, D., Chung, C., Schürer, S., Morisseau, C., Hammock, B. D., & Landry, D. W. (2009). Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorganic and Medicinal Chemistry Letters, 19(8), 2354-2359. https://doi.org/10.1016/j.bmcl.2008.09.066

Xie, Y, Liu, Y, Gong, G, Smith, DH, Yan, F, Rinderspacher, A, Feng, Y, Zhu, Z, Li, X, Deng, SX, Branden, L, Vidović, D, Chung, C, Schürer, S, Morisseau, C, Hammock, BD & Landry, DW 2009, 'Discovery of potent non-urea inhibitors of soluble epoxide hydrolase', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 8, pp. 2354-2359. https://doi.org/10.1016/j.bmcl.2008.09.066

@article{49247e5dbc384e3ca02f6d62d4702414,

title = "Discovery of potent non-urea inhibitors of soluble epoxide hydrolase",

abstract = "Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.",

keywords = "HTS, Nanomolar, Non-urea, sEH",

author = "Yuli Xie and Yidong Liu and Gangli Gong and Smith, {Deborah H.} and Fang Yan and Alison Rinderspacher and Yan Feng and Zhengxiang Zhu and Xiangpo Li and Deng, {Shi Xian} and Lars Branden and Du{\v s}ica Vidovi{\'c} and Caty Chung and Stephan Sch{\"u}rer and Christophe Morisseau and Hammock, {Bruce D.} and Landry, {Donald W.}",

note = "Funding Information: This work was supported by the NIH MLSCN Grant.",

year = "2009",

month = apr,

day = "15",

doi = "10.1016/j.bmcl.2008.09.066",

language = "English (US)",

volume = "19",

pages = "2354--2359",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

AU - Xie, Yuli

AU - Liu, Yidong

AU - Gong, Gangli

AU - Smith, Deborah H.

AU - Yan, Fang

AU - Rinderspacher, Alison

AU - Feng, Yan

AU - Zhu, Zhengxiang

AU - Li, Xiangpo

AU - Deng, Shi Xian

AU - Branden, Lars

AU - Vidović, Dušica

AU - Chung, Caty

AU - Schürer, Stephan

AU - Morisseau, Christophe

AU - Hammock, Bruce D.

AU - Landry, Donald W.

N1 - Funding Information: This work was supported by the NIH MLSCN Grant.

PY - 2009/4/15

Y1 - 2009/4/15

N2 - Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.

AB - Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.

KW - HTS

KW - Nanomolar

KW - Non-urea

KW - sEH

UR - http://www.scopus.com/inward/record.url?scp=63149137137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63149137137&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2008.09.066

DO - 10.1016/j.bmcl.2008.09.066

M3 - Article

C2 - 19303288

AN - SCOPUS:63149137137

SN - 0960-894X

VL - 19

SP - 2354

EP - 2359

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this