Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

Yuli Xie, Yidong Liu, Gangli Gong, Deborah H. Smith, Fang Yan, Alison Rinderspacher, Yan Feng, Zhengxiang Zhu, Xiangpo Li, Shi Xian Deng, Lars Branden, Dušica Vidović, Caty Chung, Stephan Schürer, Christophe Morisseau, Bruce D. Hammock, Donald W. Landry

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.

Original languageEnglish (US)
Pages (from-to)2354-2359
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number8
StatePublished - Apr 15 2009
Externally publishedYes


  • HTS
  • Nanomolar
  • Non-urea
  • sEH

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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