Discovery of potent non-urea inhibitors of soluble epoxide hydrolase

Yuli Xie, Yidong Liu, Gangli Gong, Deborah H. Smith, Fang Yan, Alison Rinderspacher, Yan Feng, Zhengxiang Zhu, Xiangpo Li, Shi Xian Deng, Lars Branden, Dušica Vidović, Caty Chung, Stephan Schürer, Christophe Morisseau, Bruce D. Hammock, Donald W. Landry

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.

Original languageEnglish (US)
Pages (from-to)2354-2359
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number8
DOIs
StatePublished - Apr 15 2009
Externally publishedYes

Fingerprint

Epoxide Hydrolases
Chemical modification
Blood Vessels
Screening
Throughput
Hypertension
Inflammation

Keywords

  • HTS
  • Nanomolar
  • Non-urea
  • sEH

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Xie, Y., Liu, Y., Gong, G., Smith, D. H., Yan, F., Rinderspacher, A., ... Landry, D. W. (2009). Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorganic and Medicinal Chemistry Letters, 19(8), 2354-2359. https://doi.org/10.1016/j.bmcl.2008.09.066

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. / Xie, Yuli; Liu, Yidong; Gong, Gangli; Smith, Deborah H.; Yan, Fang; Rinderspacher, Alison; Feng, Yan; Zhu, Zhengxiang; Li, Xiangpo; Deng, Shi Xian; Branden, Lars; Vidović, Dušica; Chung, Caty; Schürer, Stephan; Morisseau, Christophe; Hammock, Bruce D.; Landry, Donald W.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 8, 15.04.2009, p. 2354-2359.

Research output: Contribution to journalArticle

Xie, Y, Liu, Y, Gong, G, Smith, DH, Yan, F, Rinderspacher, A, Feng, Y, Zhu, Z, Li, X, Deng, SX, Branden, L, Vidović, D, Chung, C, Schürer, S, Morisseau, C, Hammock, BD & Landry, DW 2009, 'Discovery of potent non-urea inhibitors of soluble epoxide hydrolase', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 8, pp. 2354-2359. https://doi.org/10.1016/j.bmcl.2008.09.066
Xie, Yuli ; Liu, Yidong ; Gong, Gangli ; Smith, Deborah H. ; Yan, Fang ; Rinderspacher, Alison ; Feng, Yan ; Zhu, Zhengxiang ; Li, Xiangpo ; Deng, Shi Xian ; Branden, Lars ; Vidović, Dušica ; Chung, Caty ; Schürer, Stephan ; Morisseau, Christophe ; Hammock, Bruce D. ; Landry, Donald W. / Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 8. pp. 2354-2359.
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