Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Brian Metcalf, Chihyuan Chuang, Kobina Dufu, Mira P. Patel, Abel Silva-Garcia, Carl Johnson, Qing Lu, James R. Partridge, Larysa Patskovska, Yury Patskovsky, Steven C. Almo, Matthew P. Jacobson, Lan Hua, Qing Xu, Stephen L. Gwaltney, Calvin Yee, Jason Harris, Bradley P. Morgan, Joyce James, Donghong XuAthiwat Hutchaleelaha, Kumar Paulvannan, Donna Oksenberg, Zhe Li

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