Disaggregation of particles with biospecific interactions in shear flow

Andrei A. Potanin, Vladislav V. Verkhusha, Vladimir M. Muller

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The disaggregation of biospecifically interacting particles in shear flow is studied on the basis of kinetic modeling of formation and breakup of ligand-receptor bonds. The reaction rate theory is employed to improve earlier estimations of the critical force required to separate the surfaces. A chain of particles connected through ligand-receptor bonds responds to an external load as a contorted elastic rod. The breakup of the many-particle aggregate is attributed to the rupture of the backbone rod-like chain of particles. The theoretical model is found to be in good agreement with our experimental data on disaggregation of particles of latex immunoconjugates and blood platelets in shear flow.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalJournal of Colloid And Interface Science
Volume188
Issue number2
DOIs
StatePublished - Apr 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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